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Aurora kinase inhibitor-2

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Chemical Structure| 331770-21-9 同义名 : Aurora Kinase Inhibitor II;4-(4ʹ-Benzamidoanilino)-6,7-dimethoxyquinazoline;IUN-70219
CAS号 : 331770-21-9
货号 : A1210118
分子式 : C23H20N4O3
纯度 : 97%
分子量 : 400.43
MDL号 : MFCD13191283
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(262.22 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Aurora kinase inhibitor-2 is a selective, ATP-competitive inhibitor of Aurora kinase, with IC50 values of 310 nM for Aurora kinase A and 240 nM for Aurora kinase B. Aurora kinase inhibitor-2 has been shown to be effective in an antiproliferative assay on MCF7 cells (IC50 value of 1.25 µM)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.50mL

0.50mL

0.25mL

12.49mL

2.50mL

1.25mL

24.97mL

4.99mL

2.50mL
参考文献

[1]Andrew A Mortlock, et al. Progress in the development of selective inhibitors of aurora kinases. Curr Top Med Chem. 2005;5(8):807-21.