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Atosiban

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Chemical Structure| 90779-69-4 同义名 : RW22164;RWJ22164;Tractocile;ORF 22164;Antocin;Atosiban Acetate
CAS号 : 90779-69-4
货号 : A600380
分子式 : C43H67N11O12S2
纯度 : 99+%
分子量 : 994.19
MDL号 : MFCD00672436
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 16 mg/mL(16.09 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 15 mg/mL(15.09 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Atosiban is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban inhibits the oxytocin-mediated release of IP3 from the myometrial cell membrane. There is reduced release of intracellular, stored calcium from the sacroplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, Atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua[3]. Atosiban resulted in fewer maternal side-effects than nifedipine, with no difference in pregnancy prolongation[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00599898 Labor, Premature Phase 4 Completed - Israel ... 展开 >> HaEmek Medical Center Afula, Israel, 18100 收起 <<
NCT01796522 Preterm Delivery. Phase 3 Withdrawn(have been published ... 展开 >>new studies that it showed the ineffectiveness of the treatments proposed in this study.) 收起 << May 2013 Spain ... 展开 >> Hospital Universitari y Politécnic La Fe Valencia, Spain, 46026 收起 <<
NCT02292784 Obstetric Labour, Premature Phase 2 Phase 3 Recruiting July 29, 2022 -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.01mL

0.20mL

0.10mL

5.03mL

1.01mL

0.50mL

10.06mL

2.01mL

1.01mL
参考文献

[1]Sanu O, Lamont RF. Critical appraisal and clinical utility of atosiban in the management of preterm labor. Ther Clin Risk Manag. 2010 Apr 26;6:191-9.

[2]Akerlund M, Carlsson AM, et al. The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin. Acta Obstet Gynecol Scand. 1985;64(6):499-504.

[3]Sanu O, Lamont RF. Critical appraisal and clinical utility of atosiban in the management of preterm labor. Ther Clin Risk Manag. 2010 Apr 26;6:191-9

[4]Ali AA, Sayed AK, El Sherif L, Loutfi GO, Ahmed AMM, Mohamed HB, Anwar AT, Taha AS, Yahia RM, Elgebaly A, Abdel-Daim MM. Systematic review and meta-analysis of randomized controlled trials of atosiban versus nifedipine for inhibition of preterm labor. Int J Gynaecol Obstet. 2019 May;145(2):139-148