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阿斯巴甜 /Aspartame {[allProObj[0].p_purity_real_show]}

货号：A247979 同义名： SC-18862;L-Aspartyl-L-Phenylalanine methyl ester

Aspartame is an artificial non-saccharide sweetener used as a sugar substitute in some foods and beverages. It is a methyl ester of the aspartic acid/phenylalanine dipeptide.

Aspartame 化学结构 CAS号：22839-47-0
Aspartame 化学结构
CAS号：22839-47-0
Aspartame 3D分子结构
CAS号：22839-47-0
Aspartame 化学结构 CAS号：22839-47-0
Aspartame 3D分子结构 CAS号：22839-47-0
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Aspartame 纯度/质量文件 产品仅供科研

货号：A247979 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Aspartame 生物活性

描述 Aspartame (SC-18862), a synthetic dipeptide methyl ester, is used as a non-nutritive synthetic sweetener[1].[2].
体内研究

At a dosage of 4000 mg/kg body weight per day administered orally, aspartame has been found to have no adverse effects in acute, subacute, and chronic toxicity studies, which also investigated its decomposition products in mice, rats, hamsters, and dogs[1].
体外研究

Aspartame consists of phenylalanine, which plays a significant role in neurotransmitter regulation, aspartic acid, an excitatory neurotransmitter in the central nervous system, and methanol[2].

Aspartame 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02616484 Pyruvate Dehydrogenase Complex... 展开 >> Deficiency 收起 << Phase 3 Recruiting June 30, 2020 United States, California ... 展开 >> Children's Hospital of Orange County Not yet recruiting Orange, California, United States, 92868 Contact: Jose E Abdenur, MD    888-770-2462    jabdenur@choc.org    Stanford University Recruiting Stanford, California, United States, 94305 Contact: Gregory M Enns, M.B., Ch.B.    650-498-5798    greg.enns@stanford.edu    Contact: Thu Quan, MBA/HCM CCRC    650-736-8166    tquan@stanford.edu    United States, District of Columbia Children's National Medical Center Recruiting Washington, District of Columbia, United States, 20010 Contact: Andrea L Gropman, MD    202-476-6230    agropman@cnmc.org    United States, Florida University of Florida Recruiting Gainesville, Florida, United States, 32611 Contact: Richard Neiberger, MD    352-273-9014    neibere@peds.ufl.edu    Contact: Tracie Kurtz, RN    352-273-9014    tlkurtz@ufl.edu    United States, Ohio University Hospitals Cleveland Medical Center Recruiting Cleveland, Ohio, United States, 44106 Contact: Jirair Bedoayn, MD    215-844-3936    Jirair.Bedoyan@UHhospitals.org    Contact: Audrey Lynn, PhD    216-844-7124    audrey.lynn@uhhospitals.org    United States, Pennsylvania Children's Hospital of Philadelphia Recruiting Philadelphia, Pennsylvania, United States, 15224 Contact: Marni J Falk, MD    215-590-4564    falkm@email.chop.edu    Contact: Laura Dennis    267-426-0229    DENNISL@email.chop.edu    Children's Hospital of Pittsburgh Recruiting Pittsburgh, Pennsylvania, United States, 15224 Contact: Gerard Vockley, MD    412-692-5070    gerard.vockley@chp.edu    Contact: Jennifer Baker    412-692-6378    jennifer.baker@chp.edu    United States, Utah University of Utah Recruiting Salt Lake City, Utah, United States, 84113 Contact: Nicola Longo, MD, PhD    801-585-2457    NICOLA.LONGO@HSC.UTAH.EDU    Contact: Margaret Kuenzi, BS CCRC    801-585-9183    Margaret.Kuenzi@hsc.utah.edu    United States, Washington Seattle Children's Hospital Not yet recruiting Seattle, Washington, United States, 98105 Contact: Russell P Saneto, DO, PhD    206-987-2078    russ.saneto@seattlechildrens.org 收起 <<
NCT03708939 Glucose Intolerance ... 展开 >> Glucose, Low Blood Glucose, High Blood 收起 << Not Applicable Enrolling by invitation January 1, 2021 Israel ... 展开 >> Weizmann Institute of Science Reẖovot, Israel 收起 <<
NCT00654108 Escherichia Coli Infections Phase 1 Completed - United States, Ohio ... 展开 >> Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229-3039 收起 <<

Aspartame 参考文献

[1]Magnuson, B.A., et al., Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit Rev Toxicol, 2007. 37(8): p. 629-727.

[2]Humphries, P., E. Pretorius, and H. Naude, Direct and indirect cellular effects of aspartame on the brain. Eur J Clin Nutr, 2008. 62(4): p. 451-62.

Aspartame 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.40mL

0.68mL

0.34mL

16.99mL

3.40mL

1.70mL

33.98mL

6.80mL

3.40mL

Aspartame 技术信息

CAS号22839-47-0
分子式C14H18N2O5
分子量 294.303
别名 SC-18862;L-Aspartyl-L-Phenylalanine methyl ester;Aspartam.;Asp-phe-ome;Asp-Phe methyl ester;Nutrasweet
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Room Temperature
溶解度

DMSO: 25 mg/mL(84.95 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 5 mg/mL(16.99 mM)，配合低频超声助溶
动物实验配方

Tags: Aspartame | SC-18862;L-Aspartyl-L-Phenylalanine methyl ester;Aspartam.;Asp-phe-ome;Asp-Phe methyl ester;Nutrasweet | Medicinal Excipient | Dipeptide and Tripeptide | Artificial sweetener | AmBeed-信号通路专用抑制剂 | Aspartame 纯度/质量文件 | Aspartame 生物活性 | Aspartame 临床数据 | Aspartame 参考文献 | Aspartame 实验方案 | Aspartame 技术信息

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