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/ Arteannuin B

青蒿素B /Arteannuin B {[allProObj[0].p_purity_real_show]}

货号：A365685

Arteannuin B, a biogenetic precursor of artemisinin found in the herb artemisia annua, is active against different bacteria and certain fungal species with potential antimalarial and antitumor activities.

Arteannuin B 化学结构 CAS号：50906-56-4
Arteannuin B 化学结构
CAS号：50906-56-4
Arteannuin B 3D分子结构
CAS号：50906-56-4
Arteannuin B 化学结构 CAS号：50906-56-4
Arteannuin B 3D分子结构 CAS号：50906-56-4
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Arteannuin B 纯度/质量文件 产品仅供科研

货号：A365685 标准纯度： {[allProObj[0].p_purity_real_show]}
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产品名称 Ferroptosis ↓ 其他靶点 纯度
Ferrostatin-1 ++

Ferroptosis, EC50: 60 nM

 		98%
Liproxstatin-1 +++

ferroptosis, IC50: 22 nM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Arteannuin B 生物活性

描述 Arteannuin B, a biogenetic precursor of artemisinin found in the herb artemisia annua, is active against different bacteria and certain fungal species with potential antimalarial and antitumor activities[1]. Arteannuin B showed the highest anti-SARS-CoV-2 potential with an EC50 of 10.28 ± 1.12 μM[2]. Moreover, compatibility of artemisinin, scopoletin, arteannuin B and arteannuic acid has antimalarial effect. Compatibility of scopoletin, arteannuin B and arteannuic acid is conducive to resolving summerheat-heat[3]. The overexpression of AaHDR1 (an Artemisia annua HDR cDNA) increased contents of artemisinin, arteannuin B and other sesquiterpenes, and multiple monoterpenes[4]. All sesquiterpenes (artemisinin, dihydroartemisinin, artemisinic acid, arteannuin B) significantly reduced production of PGE2 (prostaglandin E2). Arteannuin B also inhibited production of NO (nitric oxide) and secretion of cytokines[5].

Arteannuin B 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03093129 Colorectal Cancer Phase 2 Recruiting December 2022 Vietnam ... 展开 >> 108 Military Central Hospital Recruiting Hanoi, Vietnam Contact: Le Huu Song, MD, PhD    +84 (0) 974845270    lehuusong@108-icid.com    Contact: Bui Tien Sy, MD, PhD    +84 (0) 974552943    tiensy2015@yahoo.com    Principal Investigator: Le Huu Song, MD, PhD 收起 <<
NCT01668433 G6PD Normal G... 展开 >>6PD Deficient Healthy 收起 << Phase 1 Completed - Thailand ... 展开 >> Hospital for Tropical Diseases Bangkok, Thailand, 10400 收起 <<
NCT01704508 Malaria Phase 4 Unknown January 2015 Guinea-Bissau ... 展开 >> Bandim Health Project Recruiting Bissau, Guinea-Bissau Contact: Amabelia Rodrigues, MD, ph.d.       a.rodrigues@bandim.org    Principal Investigator: Amabelia Rodrigues, MD, ph.d. 收起 <<

Arteannuin B 参考文献

[1]Wang Y, Huang W, Wang N, Ouyang D, Xiao L, Zhang S, Ou X, He T, Yu R, Song L. Development of Arteannuin B Sustained-Release Microspheres for Anti-Tumor Therapy by Integrated Experimental and Molecular Modeling Approaches. Pharmaceutics. 2021 Aug 11;13(8):1236

[2]Cao R, Hu H, Li Y, Wang X, Xu M, Liu J, Zhang H, Yan Y, Zhao L, Li W, Zhang T, Xiao D, Guo X, Li Y, Yang J, Hu Z, Wang M, Zhong W. Anti-SARS-CoV-2 Potential of Artemisinins In Vitro. ACS Infect Dis. 2020 Sep 11;6(9):2524-2531

[3]Zhang X, Zhao Y, Guo L, Qiu Z, Huang L, Qu X. Differences in chemical constituents of Artemisia annua L from different geographical regions in China. PLoS One. 2017 Sep 7;12(9):e0183047

[4]Ma D, Li G, Zhu Y, Xie DY. Overexpression and Suppression of Artemisia annua 4-Hydroxy-3-Methylbut-2-enyl Diphosphate Reductase 1 Gene (AaHDR1) Differentially Regulate Artemisinin and Terpenoid Biosynthesis. Front Plant Sci. 2017 Jan 31;8:77

[5]Zhu XX, Yang L, Li YJ, Zhang D, Chen Y, Kostecká P, Kmoníčková E, Zídek Z. Effects of sesquiterpene, flavonoid and coumarin types of compounds from Artemisia annua L. on production of mediators of angiogenesis. Pharmacol Rep. 2013;65(2):410-20

Arteannuin B 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.03mL

0.81mL

0.40mL

20.14mL

4.03mL

2.01mL

40.27mL

8.05mL

4.03mL

Arteannuin B 技术信息

CAS号50906-56-4
分子式C15H20O3
分子量 248.317
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,2-8°C
溶解度

DMSO: 25 mg/mL(100.68 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Arteannuin B | Ferroptosis | SARS-CoV | Artemisia | Terpenes | AmBeed-信号通路专用抑制剂 | Arteannuin B 纯度/质量文件 | Arteannuin B 亚型比较 | Arteannuin B 生物活性 | Arteannuin B 临床数据 | Arteannuin B 参考文献 | Arteannuin B 实验方案 | Arteannuin B 技术信息

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