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Arteannuin B

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Chemical Structure| 50906-56-4 同义名 : -
CAS号 : 50906-56-4
货号 : A365685
分子式 : C15H20O3
纯度 : 99%+
分子量 : 248.317
MDL号 : MFCD09859140
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(100.68 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Arteannuin B, a biogenetic precursor of artemisinin found in the herb artemisia annua, is active against different bacteria and certain fungal species with potential antimalarial and antitumor activities[1]. Arteannuin B showed the highest anti-SARS-CoV-2 potential with an EC50 of 10.28 ± 1.12 μM[2]. Moreover, compatibility of artemisinin, scopoletin, arteannuin B and arteannuic acid has antimalarial effect. Compatibility of scopoletin, arteannuin B and arteannuic acid is conducive to resolving summerheat-heat[3]. The overexpression of AaHDR1 (an Artemisia annua HDR cDNA) increased contents of artemisinin, arteannuin B and other sesquiterpenes, and multiple monoterpenes[4]. All sesquiterpenes (artemisinin, dihydroartemisinin, artemisinic acid, arteannuin B) significantly reduced production of PGE2 (prostaglandin E2). Arteannuin B also inhibited production of NO (nitric oxide) and secretion of cytokines[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03093129 Colorectal Cancer Phase 2 Recruiting December 2022 Vietnam ... 展开 >> 108 Military Central Hospital Recruiting Hanoi, Vietnam Contact: Le Huu Song, MD, PhD    +84 (0) 974845270    lehuusong@108-icid.com    Contact: Bui Tien Sy, MD, PhD    +84 (0) 974552943    tiensy2015@yahoo.com    Principal Investigator: Le Huu Song, MD, PhD 收起 <<
NCT01668433 G6PD Normal G... 展开 >>6PD Deficient Healthy 收起 << Phase 1 Completed - Thailand ... 展开 >> Hospital for Tropical Diseases Bangkok, Thailand, 10400 收起 <<
NCT01704508 Malaria Phase 4 Unknown January 2015 Guinea-Bissau ... 展开 >> Bandim Health Project Recruiting Bissau, Guinea-Bissau Contact: Amabelia Rodrigues, MD, ph.d.       a.rodrigues@bandim.org    Principal Investigator: Amabelia Rodrigues, MD, ph.d. 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.03mL

0.81mL

0.40mL

20.14mL

4.03mL

2.01mL

40.27mL

8.05mL

4.03mL
参考文献

[1]Wang Y, Huang W, Wang N, Ouyang D, Xiao L, Zhang S, Ou X, He T, Yu R, Song L. Development of Arteannuin B Sustained-Release Microspheres for Anti-Tumor Therapy by Integrated Experimental and Molecular Modeling Approaches. Pharmaceutics. 2021 Aug 11;13(8):1236

[2]Cao R, Hu H, Li Y, Wang X, Xu M, Liu J, Zhang H, Yan Y, Zhao L, Li W, Zhang T, Xiao D, Guo X, Li Y, Yang J, Hu Z, Wang M, Zhong W. Anti-SARS-CoV-2 Potential of Artemisinins In Vitro. ACS Infect Dis. 2020 Sep 11;6(9):2524-2531

[3]Zhang X, Zhao Y, Guo L, Qiu Z, Huang L, Qu X. Differences in chemical constituents of Artemisia annua L from different geographical regions in China. PLoS One. 2017 Sep 7;12(9):e0183047

[4]Ma D, Li G, Zhu Y, Xie DY. Overexpression and Suppression of Artemisia annua 4-Hydroxy-3-Methylbut-2-enyl Diphosphate Reductase 1 Gene (AaHDR1) Differentially Regulate Artemisinin and Terpenoid Biosynthesis. Front Plant Sci. 2017 Jan 31;8:77

[5]Zhu XX, Yang L, Li YJ, Zhang D, Chen Y, Kostecká P, Kmoníčková E, Zídek Z. Effects of sesquiterpene, flavonoid and coumarin types of compounds from Artemisia annua L. on production of mediators of angiogenesis. Pharmacol Rep. 2013;65(2):410-20