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芹菜素 /Apigenin {[allProObj[0].p_purity_real_show]}

货号：A167323 同义名： 金银花 / 4',5,7-Trihydroxyflavone;Apigenol

Apigenin 是一种天然黄酮类化合物，具有抗炎、抗氧化和抗肿瘤活性。Apigenin 主要用于癌症研究、抗炎研究以及作为食品补充剂用于抗氧化和预防慢性疾病的研究。Apigenin (Standard) 是 Apigenin 的分析标准品。本产品用于研究及分析应用。

Apigenin 化学结构 CAS号：520-36-5
Apigenin 化学结构
CAS号：520-36-5
Apigenin 3D分子结构
CAS号：520-36-5
Apigenin 化学结构 CAS号：520-36-5
Apigenin 3D分子结构 CAS号：520-36-5
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Apigenin 纯度/质量文件 产品仅供科研

货号：A167323 标准纯度： {[allProObj[0].p_purity_real_show]}
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全球学术期刊中引用的产品

• Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]
• JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]
• BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]
• J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]
• PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]
更多 >

Apigenin 生物活性

描述 CYP2C9 ranks among the most important drug-metabolizing enzymes in humans and hydroxylates 10 to 20% of commonly prescribed drugs[3]. Apigenin, a naturally occurring plant flavone, abundantly present in common fruits and vegetables, is a competitive CYP2C9 inhibitor with a Ki value of 2 μM[3]. It inhibited T-24 cell proliferation in a dose-dependent manner. Apigenin-mediated subG1 phase accumulation was also associated with an increase in the phospho-p53, p53, p21, and p27 levels, and with a decrease in the Cyclin A, Cyclin B1, Cyclin E, CDK2, Cdc2, and Cdc25C levels, thereby blocking cell cycle progression. In addition, apigenin increased the Bax, Bad, and Bak levels, but reduced the Bcl-xL, Bcl-2, and Mcl-1levels, and subsequently triggered the mitochondrial apoptotic pathway. Further analysis demonstrated that apigenin increased the reactive oxygen species (ROS) levels and depleted GSH in T-24 cells at 12h[4]. Apigenin inhibited protein kinase C (PKC) by competing with adenosine triphosphate (ATP). It also reduced the level of tetradecanoyl-phorbol-13-acetate (TPA)-stimulated phosphorylation of cellular proteins and inhibited TPA-induced c-jun and c-fos expression and exhibited the reverting effect on the transformed morphology of these cells[5]. In ovalbumin immunized BALB/C mice, production of IL-4 was down-regulated by apigenin[6]. In vivo studies have also shown that apigenin inhibits melanoma lung metastases by impairing interaction of tumor cells with endothelium. Oral administration of apigenin was shown to cause a significant increase in uterine weight and overall uterine concentration of estrogen receptor (ER)-α in female mice, and also suppresses prostate and breast cancer cell growth through estrogen receptor β1[6].

Apigenin 细胞研究

细胞系 浓度 检测类型 检测时间 活动说明 数据源
HEK293 cells Function assay 24 h Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assay, EC50=24.9 μM 24955889
HEK293 FS cells Function assay Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay, IC50=1.13 μM 20731357
human H295R cells Function assay Inhibition of aromatase expressed in human H295R cells, IC50=1 μM 18778944
human H9 cells Function assay 3 days Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay, EC50=9 μM 8158164

Apigenin 动物研究

Dose Rat: 10 mg/kg - 20 mg/kg[3] (p.o.) Mice: 25 mg/kg - 200 mg/kg[4] (i.p.); 5 mg/kg - 20 mg/kg[5] (p.o.)
Administration p.o., i.p.

Apigenin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03365648 Allergic Rhinoconjunctivitis Not Applicable Completed - Italy ... 展开 >> Fondazione IRCCS Policlinico San Matteo Pavia, (pv), Italy, 27100 Ospedale regionale San Salvatore - ASL 1 Avezzano Sulmona L'Aquila L'Aquila, AQ, Italy, 67100 A.O.U. Consorziale "Policlinico Giovanni XXIII" Bari, BA, Italy, 70126 A.O.U. Consorziale "Policlinico-Giovanni XXIII" Bari, BA, Italy, 70126 A.O.U. Policlinico Vittorio Emanuele Catania, CT, Italy, 95123 Istituto Giannina Gaslini Genova, GE, Italy, 16132 P.O. San Giovanni di Dio - ASP di Crotone Crotone, KR, Italy, 88900 A.O.U. Policlinico "G. Martino" Messina, ME, Italy, 98124 P.O. G. Salvini di Garbagnate Milanese - ASST Rhodense Garbagnate Milanese, MI, Italy, 20042 Ospedale Civile di Legnano - ASST Ovest Milanese Legnano, MI, Italy, 20162 Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milano, MI, Italy, 20122 Ospedale San Carlo Borromeo - ASST Azienda Socio Sanitaria Territoriale Santi Paolo E Carlo Milano, MI, Italy, 20157 Ospedale Città di Sesto San Giovanni - ASST Nord Milano Sesto San Giovanni, MI, Italy, 20099 Ospedale di Polistena "Santa Maria degli Ungheresi" - ASP di Reggio Calabria Polistena, RC, Italy, 89024 A.O.U. Policlinico Umberto I Roma, RM, Italy, 00161 P.O. di Busto Arsizio - ASST Valle Olona Busto Arsizio, VA, Italy, 21051 Az. Osp. Univ. dell'Università degli Studi della Campania "Luigi Vanvitelli" Napoli, Italy, 80138 收起 <<
NCT01286324 Primary Insomnia ... 展开 >> Chronic Insomnia 收起 << Phase 2 Completed - United States, Michigan ... 展开 >> University of Michigan Department of Family Medicine Ann Arbor, Michigan, United States, 48105 收起 <<
NCT03139227 Health Status Unknown Not Applicable Recruiting August 31, 2020 United States, Ohio ... 展开 >> Ohio State University Comprehensive Cancer Center Recruiting Columbus, Ohio, United States, 43210 Contact: Sagar D. Sardesai, MBBS    614-293-0066    Sagar.Sardesai@osumc.edu    Principal Investigator: Sagar D. Sardesai, MBBS          Sub-Investigator: Andrea I. Doseff, PhD          Sub-Investigator: Maryam Lustberg, MD MPH 收起 <<

Apigenin 参考文献

[1]Harrison ME, Power Coombs MR, et al. Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt. Exp Mol Pathol. 2014 Oct;97(2):211-7.

[2]Lv X, Qiu M, et al. Apigenin inhibits enterovirus 71 replication through suppressing viral IRES activity and modulating cellular JNK pathway. Antiviral Res. 2014 Sep;109:30-41.

[3]Si D, Wang Y, Zhou YH, Guo Y, Wang J, Zhou H, Li ZS, Fawcett JP. Mechanism of CYP2C9 inhibition by flavones and flavonols. Drug Metab Dispos. 2009 Mar;37(3):629-34. doi: 10.1124/dmd.108.023416. Epub 2008 Dec 12. PMID: 19074529.

[4]Shi MD, Shiao CK, Lee YC, Shih YW. Apigenin, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis. Cancer Cell Int. 2015 Mar 29;15:33. doi: 10.1186/s12935-015-0186-0. PMID: 25859163; PMCID: PMC4391114.

[5]Lin JK, Chen YC, Huang YT, Lin-Shiau SY. Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J Cell Biochem Suppl. 1997;28-29:39-48. PMID: 9589348.

[6]Shukla S, Gupta S. Apigenin: a promising molecule for cancer prevention. Pharm Res. 2010 Jun;27(6):962-78. doi: 10.1007/s11095-010-0089-7. Epub 2010 Mar 20. PMID: 20306120; PMCID: PMC2874462.

Apigenin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.70mL

0.74mL

0.37mL

18.50mL

3.70mL

1.85mL

37.01mL

7.40mL

3.70mL

Apigenin 技术信息

CAS号520-36-5
分子式C15H10O5
分子量 270.23
别名 金银花 ;4',5,7-Trihydroxyflavone;Apigenol;457Trihydroxyflavone;Spigenin;Apigenine;Versulin;Flavone;Chamomile;NSC 83244;LY 080400;C.I. Natural Yellow 1
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C
溶解度

DMSO: 85 mg/mL(314.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

IP 2% DMSO+2% Tween80+40% PEG300+water 4 mg/mL clear

PO 0.5% CMC-Na 41 mg/mL suspension

Tags: Apigenin | 4',5,7-Trihydroxyflavone;Apigenol;457Trihydroxyflavone;Spigenin;Apigenine;Versulin;Flavone;Chamomile;NSC 83244;LY 080400;C.I. Natural Yellow 1 | 金银花 | Plant Standard | P450 | AmBeed-信号通路专用抑制剂 | Apigenin 纯度/质量文件 | Apigenin 生物活性 | Apigenin 细胞研究 | Apigenin 动物研究 | Apigenin 临床数据 | Apigenin 参考文献 | Apigenin 实验方案 | Apigenin 技术信息

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