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胺碘酮 /Amiodarone {[allProObj[0].p_purity_real_show]}

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Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.

Amiodarone 化学结构 CAS号:1951-25-3
Amiodarone 化学结构
CAS号:1951-25-3
Amiodarone 3D分子结构
CAS号:1951-25-3
Amiodarone 化学结构 CAS号:1951-25-3
Amiodarone 3D分子结构 CAS号:1951-25-3
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Amiodarone 纯度/质量文件 产品仅供科研

货号:A262295 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 Potassium Channel 其他靶点 纯度
Tolbutamide 98%
Glimepiride ++++

SUR2B, IC50: 7.3 nM

SUR1, IC50: 5.4 nM

97%
Dronedarone Hydrochloride 95%
Gliquidone ++

Potassium channel, IC50: 27.2 nM

98%
TRAM-34 +++

IKCa1 (KCa3.1), Kd: 20 nM

98%
Glibenclamide 98%
Amiodarone HCl 97%
Gliclazide ++

Potassium channel, IC50: 184 nM

98%
Repaglinide 98%
Dofetilide 98%
Nateglinide 99%
Quinine hydrochloride dihydrate 98%
ML133 HCl +

Kir2.1, IC50: 290 nM

97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Amiodarone 生物活性

描述 Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.

Amiodarone 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01082055 - Completed - United Kingdom ... 展开 >> Univeristy of Dundee Dundee, United Kingdom, DD1 9SY 收起 <<
NCT03269383 Atrial Fibrillation Phase 4 Not yet recruiting December 2018 United States, Maine ... 展开 >> Maine Medical Center Not yet recruiting Portland, Maine, United States, 04102 Contact: Janelle Richard, BA, CCRP    207-662-2862    richaj3@mmc.org    Principal Investigator: Chris Connors, MD 收起 <<
NCT02248753 Atrial Fibrillation Not Applicable Active, not recruiting October 2019 Netherlands ... 展开 >> VU University Medical Center Amsterdam, Netherlands Amphia Hospital Breda, Netherlands Catharina Ziekenhuis Eindhoven, Netherlands Medisch Spectrum Twente Enschede, Netherlands University Medical Center Groningen Groningen, Netherlands Zuyderland Medical Center Heerlen, Netherlands Alrijne Hospital Leiderdorp, Netherlands Maastricht University Medical Center Maastricht, Netherlands St. Antonius Hospital Nieuwegein, Netherlands Franciscus Gasthuis Rotterdam, Netherlands Antonius Ziekenhuis Sneek, Netherlands HagaZiekenhuis The Hague, Netherlands St. Elisabeth - TweeSteden Hospital Tilburg, Netherlands Diakonessenhuis Utrecht, Netherlands VieCuri Medical Center Venlo, Netherlands 收起 <<

Amiodarone 参考文献

[1]Simonen P, Lehtonen J,. Desmosterol accumulation in users of amiodarone. J Intern Med. 2017 Sep 1.

[2]Wang AG, Cheng HC. Amiodarone-Associated Optic Neuropathy: Clinical Review. Neuroophthalmology. 2016 Nov 18;41(2):55-58.

Amiodarone 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.55mL

0.31mL

0.15mL

7.75mL

1.55mL

0.77mL

15.50mL

3.10mL

1.55mL

Amiodarone 技术信息

CAS号1951-25-3
分子式C25H29I2NO3
分子量 645.312
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

溶解度
动物实验配方
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