There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Amifostine thiol (WR-1065), an active metabolite of the cytoprotector Amifostine, exhibits cytoprotective and radioprotective properties. It activates p53 through a JNK-dependent signaling pathway [1][2][3].
体外研究
Amifostine thiol mitigates the direct and delayed adverse effects of both high and low-LET radiation exposures [1].
Amifostine thiol mitigates both radiation-induced DNA damage and G1-phase arrest [1].
Amifostine thiol (4 mM; 30 minutes) shields RKO36 cells from chromosomal damage and death caused by ionizing radiation [1].
Amifostine thiol (4 mM; 30 minutes) confers protection against delayed genomic instability in irradiated RKO36 cells [1].
Amifostine thiol exhibits cytotoxicity to RKO36 cells at millimolar concentrations, particularly with continuous treatment [1].
Amifostine thiol at 40 μM shields RKO36 cells from delayed genomic instability but does not prevent cell death or immediate chromosomal damage [1].
Amifostine thiol triggers JNK activation, leading to the phosphorylation of p53 at threonine 81 [2].
Amifostine thiol influences the phosphorylation of topoisomerase IIα, resulting in alterations in enzyme activity and cell cycle progression in CHO AA8 cells [3].
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