Allopurinol sodium is a highly effective and orally active inhibitor of xanthine oxidase, with an IC50 ranging from 0.2 to 50 μM. It is commonly utilized in the study of hyperuricemia and gout. Beyond its primary application, Allopurinol sodium is known to decrease the expression of HIF-1α and HIF-2α proteins, exhibiting potential in reducing hypoxia-induced factors. Additionally, it has demonstrated antidepressant, anti-nociceptive, and anti-leishmanial activities[1].[2].[3].[4].[5].
体内研究
In vivo, when administered orally at a dose of 39 mg/kg daily for 21 consecutive days, Allopurinol sodium shows antidepressant activity in mice[3].
Furthermore, administered intraperitoneally at doses ranging from 10 to 400 mg/kg, it induces significant anti-nociceptive effects in mice[4].
体外研究
In cell-based studies, Allopurinol sodium at concentrations of 0, 10, 100, and 1000 µg/ml over 17 hours significantly reduces the expression of HIF-1α and HIF-2α in HFF (human fibroblasts) and HUVEC (human umbilical vein endothelial cells) cells. Over a 24-hour period at the same concentrations, it also reduces angiogenesis traits in HUVEC cells[5].
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