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Allopurinol sodium

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Chemical Structure| 17795-21-0 同义名 : -
CAS号 : 17795-21-0
货号 : A519832
分子式 : C5H3N4NaO
纯度 : 99%+
分子量 : 158.093
MDL号 : MFCD12965022
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 50 mg/mL(316.27 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 Allopurinol sodium is a highly effective and orally active inhibitor of xanthine oxidase, with an IC50 ranging from 0.2 to 50 μM. It is commonly utilized in the study of hyperuricemia and gout. Beyond its primary application, Allopurinol sodium is known to decrease the expression of HIF-1α and HIF-2α proteins, exhibiting potential in reducing hypoxia-induced factors. Additionally, it has demonstrated antidepressant, anti-nociceptive, and anti-leishmanial activities[1].[2].[3].[4].[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.33mL

1.27mL

0.63mL

31.63mL

6.33mL

3.16mL

63.25mL

12.65mL

6.33mL
参考文献

[1]Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006;58(1):87-114.

[2]Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5(5):469-472.

[3]Karve AV, et al. Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice. Indian J Pharmacol. 2013 May-Jun;45(3):244-7.

[4]Schmidt AP, et al. Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. Br J Pharmacol. 2009 Jan;156(1):163-72.

[5]Sun Y, et al. Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. PLoS One. 2015 Apr 1;10(4):e0123649.