Alfacalcidol是一种维生素 D3 的衍生物，非选择性地激活维生素 D 受体 (VDR) ，用于骨质疏松相关的研究。
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Alfacalcidol is a non-selective VDR activator medication[3]. Alfacalcidol possesses immunoregulatory effects in vitro and in vivo by inhibiting the cytokines IL-1, IL-6, TNF-alpha and particularly IL-12. Therapy with alfacalcidol results in increased production of Th2 helper cells which produce bone protective cytokines like IL-4 and IL-10. Alfacalcidol retards corticosteroid-induced bone loss in contrast to plain vitamin D. Due to its immunomodulating properties, alfacalcidol is particularly suitable for RA(rheumatoid arthritis)-induced bone loss and for the prevention of transplantation osteoporosis, and an adjuvant contribution to the disease-modifying therapy of RA and to the immunosuppressive therapy after transplantation can not be excluded[4]. Alfacalcidol (0.025-0.1 mg/kg; p.o.; five times a week; for 3 months) exerts bone-protective effects independently of its Ca-related effects, and is in this respect superior to vitamin D(3), and that the skeletal actions of alfacalcidol take place, at least in part, independently of suppression of PTH(parathyroid hormone)[5].
United States, Arizona
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University of Arizona College of Medicine
Not yet recruiting
Phoenix, Arizona, United States, 85004
Contact: Nathalie Zeitouni, MD 602-406-8222 Nathalie.Zeitouni@dignityhealth.org
Sub-Investigator: Nathalie Zeitouni, MD
United States, Ohio
Cleveland Clinic
Recruiting
Cleveland, Ohio, United States, 44195
Contact: Jeff Negrey, MA 216-636-5504 negreyj2@ccf.org
Principal Investigator: Edward Maytin, MD
Sub-Investigator: Christine Warren, MD 收起 <<
United States, Arizona
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University of Arizona College of Medicine
Not yet recruiting
Phoenix, Arizona, United States, 85004
Contact: Nathalie Zeitouni, MD 602-406-8222 Nathalie.Zeitouni@dignityhealth.org
Sub-Investigator: Nathalie Zeitouni, MD
United States, Ohio
Cleveland Clinic
Recruiting
Cleveland, Ohio, United States, 44195
Contact: Jeff Negrey, MA 216-636-5504 negreyj2@ccf.org
Principal Investigator: Edward Maytin, MD
Sub-Investigator: Christine Warren, MD 收起 <<
Sweden
... 展开 >> Stockholm Cystic Fibrosis Center, Karolinska University Hospital Huddinge
Recruiting
Stockholm, Sweden, 141 86
Contact: Lena Hjelte, Professor 0046858587359 Lena.Hjelte@karolinska.se 收起 <<
United States, California
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UCLA Clinical and Translational Research Center (CTRC)
Not yet recruiting
Los Angeles, California, United States, 90095
Contact: Albert Shieh, MD 424-248-5617 ashieh@mednet.ucla.edu
Contact: Gloria Kiel (310) 825-1394 gskiel@mednet.ucla.edu
Principal Investigator: John S Adams, MD
Sub-Investigator: Albert Shieh, MD
University of California, Los Angeles
Recruiting
Los Angeles, California, United States, 90095 收起 <<
United States, Massachusetts
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Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
Boston, Massachusetts, United States, 02111 收起 <<
Vitamin D Deficiency
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Early Phase 1
Recruiting
May 2019
United States, Massachusetts
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Solomon Carter Fuller Mental Health Center
Recruiting
Boston, Massachusetts, United States, 02118
Contact: Michael F Holick, MD, PhD 617-638-4546 mfholick@bu.edu 收起 <<
United States, Illinois
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Northwestern University Feinberg School of Medicine, Department of Dermatology
Chicago, Illinois, United States, 60611 收起 <<
United States, New York
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Winthrop University Hospital Dialysis Unit
Mineola, New York, United States, 11023
Winthrop University Hospital
Mineola, New York, United States, 11501 收起 <<
France
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Recruiting
Caen, France, 14000
Contact: Christian Marcelli, MD, PhD 0231063093
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United States, Washington
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University of Washington
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Seattle, Washington, United States, 98195
Contact: Laura Curtin 206-221-3938 收起 <<
United States, North Carolina
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Wake Forest University Comprehensive Cancer Center
Winston-Salem, North Carolina, United States, 27157-1096 收起 <<
Hungary
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Budapest, Hungary
University of Pécs, School of Medicine
Pécs, Hungary
University of Szeged
Szeged, Hungary 收起 <<
Korea, Republic of
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Seoul National University Medical School
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Seoul, Korea, Republic of, 110-744
Contact: Chan Soo Shin, MD, PhD 82220723734 csshin@snu.ac.kr
Contact: Jung Hee Kim, MD 8220724839 jhkxingfu@gmail.com
Principal Investigator: Chan Soo Shin, MD, PhD 收起 <<
Hypovitaminosis D
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Diabetes 收起 <<
Not Applicable
Completed
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United States, Hawaii
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Lokahi Health Center
Kailua Kona, Hawaii, United States, 96740
United States, Washington
Bastyr University
Kenmore, Washington, United States, 98028 收起 <<
Cardiovascular Disease
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Phase 2
Completed
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Canada, Alberta
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Northland Hemodialysis Clinic
Calgary, Alberta, Canada, T2L 2J8
Foothills Medical Centre - University of Calgary
Calgary, Alberta, Canada, T2N 2T9
Sheldon M. Chumir Health Centre
Calgary, Alberta, Canada, T2R 0X7 收起 <<
China
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Beijing, China
Chinese PLA General Hospital
Beijing, China
Peking Union Medical College Hospital
Beijing, China
Hua Dong Hospital
Shanghai, China
The Sixth People's Hospital affiliated to Shanghai Jiaopong University
Shanghai, China 收起 <<
Autosomal Dominant Hypocalcemi... 展开 >>a or OR Primary Hypoparathyroidism Related to Other Cause But Complicated by Hypercalciuria Under Treatment 收起 <<
Phase 2
Recruiting
August 2020
France
... 展开 >> AP-HP hopital Bicetre
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Le Kremlin-Bicetre, Val-de-Marne, France, 94270
Contact: Agnes Linglart, MD agnes.linglart@aphp.fr
AP-HP Hopital Europeen Georges Pompidou
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Paris, France, 75015
Contact: Anne Blanchard, MD anne.blanchard@aphp.fr 收起 <<
Germany
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Berlin, Germany, 12200
Centre for Muscle and Bone Research, Aerpah-Kliniken Esslingen
Stuttgart, Germany, 73732 收起 <<
Indonesia
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Jakarta, Indonesia
Contact: Aulia Rizka, MD +628125265600 dr.auliarizka@yahoo.co.id 收起 <<
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