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Albendazole Sulfoxide
阿苯达唑亚砜 /Albendazole Sulfoxide
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货号：A212431
同义名：
阿苯达唑氧化物
/ Ricobendazole;Albendazole Oxide
Albendazole Sulfoxide 可以选择性地抑制β-微管蛋白聚合，用作驱虫药物。
Albendazole Sulfoxide 化学结构
Albendazole Sulfoxide 3D分子结构
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Albendazole Sulfoxide 纯度/质量文件 产品仅供科研
货号：A212431
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Albendazole Sulfoxide 质控信息
Albendazole Sulfoxide 生物活性
描述
Albendazole oxide is a derivative of albendazole that inhibits the polymerization of tubulin into microtubules. It shows high inhibitory activity against E. intestinalis in vitro with an IC50 value of 3ng/mL, which is 1.7-fold more inhibitory than albendazole[3] Encephalitozoon hellem with IC90 of <10-4 μg/mL. The IC90 values of albendazole oxide against Encephalitozoon cuniculi and Encephalitozoon intestinalis were 6×10-3 and 3.8×10-2 μg/mL, respectively[4] O -deethylase (EROD) with an IC50 of 5µM[5]
作用机制
Albendazole oxide is a sulfoxide metabolite of albendazole that inhibits tubulin polymerization[3]
Albendazole Sulfoxide 参考文献
[1] Choi JS, Han JY, et al. Foetal outcomes after exposure to albendazole in early pregnancy. J Obstet Gynaecol. 2017 Aug 1:1-4.
[2] Fattahi Masoom SH, Lari SM, et al. Albendazole therapy in human lung and liver hydatid cysts: A 13-year experience. Clin Respir J. 2017 Mar 20.
[3] Katiyar SK, Edlind TD. In vitro susceptibilities of the AIDS-associated microsporidian Encephalitozoon intestinalis to albendazole, its sulfoxide metabolite, and 12 additional benzimidazole derivatives. Antimicrob Agents Chemother. 1997;41(12):2729-2732.
[4] Ridoux O, Drancourt M. In vitro susceptibilities of the microsporidia Encephalitozoon cuniculi, Encephalitozoon hellem, and Encephalitozoon intestinalis to albendazole and its sulfoxide and sulfone metabolites. Antimicrob Agents Chemother. 1998;42(12):3301-3303.
[5] Baliharová V, Velík J, Fimanová K, et al. Inhibitory effect of albendazole and its metabolites on cytochromes P450 activities in rat and mouflon in vitro. Pharmacol Rep. 2005;57(1):97-106.
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Albendazole Sulfoxide 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
3.55mL
0.71mL
0.36mL
17.77mL
3.55mL
1.78mL
35.55mL
7.11mL
3.55mL
Albendazole Sulfoxide 技术信息
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