Albendazole Sulfoxide
产品说明书
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同义名 : | 阿苯达唑氧化物 ;Ricobendazole;Albendazole Oxide;RS 8852 |
| CAS号 : | 54029-12-8 | |
| 货号 : | A212431 | |
| 分子式 : | C12H15N3O3S | |
| 纯度 : | 97% | |
| 分子量 : | 281.331 | |
| MDL号 : | MFCD00797922 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 25 mg/mL(88.86 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Albendazole oxide is a derivative of albendazole that inhibits the polymerization of tubulin into microtubules. It shows high inhibitory activity against E. intestinalis in vitro with an IC50 value of 3ng/mL, which is 1.7-fold more inhibitory than albendazole[3]. Albendazole oxide effectively inhibited the growth of Encephalitozoon hellem with IC90 of <10-4μg/mL. The IC90 values of albendazole oxide against Encephalitozoon cuniculi and Encephalitozoon intestinalis were 6×10-3 and 3.8×10-2μg/mL, respectively[4]. In rat hepatic microsomes, albendazole oxide reduces the activity of ethoxyresorufin O-deethylase (EROD) with an IC50 of 5µM[5]. | ||
| 作用机制 | Albendazole oxide is a sulfoxide metabolite of albendazole that inhibits tubulin polymerization[3]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.55mL 0.71mL 0.36mL |
17.77mL 3.55mL 1.78mL |
35.55mL 7.11mL 3.55mL |
| 参考文献 |
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