Alantolactone

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Chemical Structure| 546-43-0 同义名 : 土木香脑 ;Alant camphor;Inula camphor;AI3-31147;NSC 93131;NSC 333843;helenine;helenin;(+)-Alantolactone
CAS号 : 546-43-0
货号 : A354359
分子式 : C15H20O2
纯度 : 98%
分子量 : 232.318
MDL号 : -
存储条件：

Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(451.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Smad3
描述 Alantolactone is a sesquiterpene lactone extracted from Inula Helenium L with anti-inflammatory, antibacterial and anticancer activities. The half maximal inhibitory effect of alantolactone on cell proliferation concentration (IC50) was 35.45 μΜ at 24 h and 24.29 μΜ at 48 h. In addition, alantolactone at 10, 20 and 30 μΜ significantly downregulated the expression levels of MMP-2, MMP-7 and MMP-9 (matrix metalloproteinase ) protein[3]. Moreover, alantolactone induced apoptosis in HepG2 cells in a dose-dependent manner. The IC50 value of alantolactone was 33 μM after 12 h treatment[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.30mL

0.86mL

0.43mL

21.52mL

4.30mL

2.15mL

43.04mL

8.61mL

4.30mL
参考文献

[1]Chun J, Li RJ, et al. Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells. Cancer Lett. 2015 Feb 1;357(1):393-403.

[2]Khan M, Yi F, et al. Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction. IUBMB Life. 2012 Sep;64(9):783-94.

[3]Liu J, Liu M, Wang S, He Y, Huo Y, Yang Z, Cao X. Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells via the p38 MAPK, NF‑κB and Nrf2 signaling pathways. Int J Mol Med. 2018 Oct;42(4):1847-1856. doi: 10.3892/ijmm.2018.3751. Epub 2018 Jul 4. PMID: 30015828; PMCID: PMC6108867.

[4]Kim M, Song K, Kim YS. Alantolactone Improves Prolonged Exposure of Interleukin-6-Induced Skeletal Muscle Inflammation Associated Glucose Intolerance and Insulin Resistance. Front Pharmacol. 2017;8:405. Published 2017 Jun 29.

[5]Khan M, Li T, Ahmad Khan MK, Rasul A, Nawaz F, Sun M, Zheng Y, Ma T. Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. Biomed Res Int. 2013;2013:719858. doi: 10.1155/2013/719858. Epub 2012 Dec 27. PMID: 23533997; PMCID: PMC3591150.