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维生素D相关/核受体
代谢酶 PPARs
/ RAR/RXR / Acitretin

阿维A /Acitretin {[allProObj[0].p_purity_real_show]}

货号：A470794 同义名： 阿曲汀 / Ro 10-1670;all-trans Acitretin

Acitretin is an analog of retinoid that can activate α-secretase ADAM10 gene expression. It has been used in the treatment of severe psoriasis.

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Type HazMat fee for 500 gram (Estimated)
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Acitretin 化学结构 CAS号：55079-83-9
Acitretin 化学结构
CAS号：55079-83-9
Acitretin 3D分子结构
CAS号：55079-83-9
Acitretin 化学结构 CAS号：55079-83-9
Acitretin 3D分子结构 CAS号：55079-83-9
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Acitretin 纯度/质量文件 产品仅供科研

货号：A470794 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Acitretin 生物活性

描述 Acitretin (Ro 10-1670) is a second-generation systemic retinoid primarily utilized for treating psoriasis. It has also been explored for potential use in Alzheimer’s disease research[1].[2].[3].
体内研究

In an experimental setting involving Alzheimer’s disease model mice, a seven-day regimen of acitretin administered intraperitoneally at a dose of 10 mg/kg was found to increase IL-6 levels in the central nervous system, indicating its influence on inflammatory processes within the brain[3].

Acitretin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00774852 Lupus Nephritis ... 展开 >> Lupus Erythematosus, Systemic 收起 << Phase 2 Completed - -
NCT02098213 Plaque Psoriasis Phase 3 Recruiting March 2019 France ... 展开 >> Station Thermale Avene Recruiting Avene, Languedoc-Rousillon, France, 34260 Principal Investigator: Didier DG GUERERO, Doctor          Thermes de Molitg les bains Recruiting Molitg, Languedoc-Roussillon, France, 66500 Principal Investigator: Patrick PP POLFLIET, Doctor          Thermes La Roche Posay Recruiting La Roche Posay, Poitou-Charentes, France, 86270 Principal Investigator: Asène AJ JELIASKOFF, Doctor          Les thermes de ST-GERVAIS Recruiting Le Fayet, Rhône-Alpe, France, 74190 Principal Investigator: Radostina RB BACHVAROVA STOYANOVA, Doctor          Etablissement thermal d'Uriage Recruiting Uriage, Rhône-Alpe, France, 38410 Principal Investigator: Murielle MB BOURGEOIS CLAVIER, Doctor 收起 <<
NCT00508547 - Recruiting September 30, 2029 -

Acitretin 参考文献

[1]Lee CS, et al. A review of acitretin, a systemic retinoid for the treatment of psoriasis. Expert Opin Pharmacother. 2005 Aug;6(10):1725-34.

[2]Sengör B, et al. Effects of acitretin on spermatogenesis of rats. J Eur Acad Dermatol Venereol. 2006 Jul;20(6):689-92.

[3]Guilherme MDS, et, al. The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients. Front Aging Neurosci. 2019 Jul 23;11:182.

Acitretin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.06mL

0.61mL

0.31mL

15.32mL

3.06mL

1.53mL

30.64mL

6.13mL

3.06mL

Acitretin 技术信息

CAS号55079-83-9
分子式C21H26O3
分子量 326.42
别名 阿曲汀 ;Ro 10-1670;all-trans Acitretin;Neotigason.;Soriatane;U0279;Ro 10-1670/000;Etretin
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度

DMSO: 18 mg/mL(55.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Acitretin | 55079-83-9 | Ro 10-1670 | RAR/RXR | RAR/RXR Agonist | Metabolic Enzyme/Protease | Vitamin D Related/Nuclear Receptor | Autophagy | Apoptosis | RAR/RXR | Autophagy | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Acitretin 纯度/质量文件 | Acitretin 生物活性 | Acitretin 临床数据 | Acitretin 参考文献 | Acitretin 实验方案 | Acitretin 技术信息

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