Acitretin | 阿曲汀 | Ro 10-1670 | RAR/RXR Agonist | AmBeed-信号通路专用抑制剂

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阿维A /Acitretin {[allProObj[0].p_purity_real_show]}

货号：A470794 同义名： 阿曲汀 / Ro 10-1670;all-trans Acitretin

Acitretin是类视黄醇化合物，能够激活α-分泌酶ADAM10基因的表达，已用于治疗重度银屑病（牛皮癣）。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Acitretin 化学结构
CAS号：55079-83-9

Acitretin 3D分子结构
CAS号：55079-83-9

规格	价格	会员价	库存	数量
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Acitretin 纯度/质量文件产品仅供科研

货号：A470794 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JMC, 2024. Ambeed. [ A919389 , A918471 , A995972 ]; • Anal. Chem., 2024, 96(50): 19947-19954. Ambeed. [ A261947 , A1165388 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A220462 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A165235 , A110205 ]; • Pharmaceutics, 2024, 16(12): 1546. Ambeed. [ A272538 , A187261 , A691302 , A506702 ]; 更多 >

Acitretin 生物活性

描述	Acitretin (Ro 10-1670) is a second-generation systemic retinoid primarily utilized for treating psoriasis. It has also been explored for potential use in Alzheimer’s disease research^[1].^[2].^[3].
体内研究	In an experimental setting involving Alzheimer’s disease model mice, a seven-day regimen of acitretin administered intraperitoneally at a dose of 10 mg/kg was found to increase IL-6 levels in the central nervous system, indicating its influence on inflammatory processes within the brain^[3].

Acitretin 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00774852	Lupus Nephritis ... 展开 >> Lupus Erythematosus, Systemic 收起 <<	Phase 2	Completed	-	-
NCT02098213	Plaque Psoriasis	Phase 3	Recruiting	March 2019	France ... 展开 >> Station Thermale Avene Recruiting Avene, Languedoc-Rousillon, France, 34260 Principal Investigator: Didier DG GUERERO, Doctor Thermes de Molitg les bains Recruiting Molitg, Languedoc-Roussillon, France, 66500 Principal Investigator: Patrick PP POLFLIET, Doctor Thermes La Roche Posay Recruiting La Roche Posay, Poitou-Charentes, France, 86270 Principal Investigator: Asène AJ JELIASKOFF, Doctor Les thermes de ST-GERVAIS Recruiting Le Fayet, Rhône-Alpe, France, 74190 Principal Investigator: Radostina RB BACHVAROVA STOYANOVA, Doctor Etablissement thermal d'Uriage Recruiting Uriage, Rhône-Alpe, France, 38410 Principal Investigator: Murielle MB BOURGEOIS CLAVIER, Doctor 收起 <<
NCT00508547	-		Recruiting	September 30, 2029	-

Acitretin 参考文献

[1]Lee CS, et al. A review of acitretin, a systemic retinoid for the treatment of psoriasis. Expert Opin Pharmacother. 2005 Aug;6(10):1725-34.

[2]Sengör B, et al. Effects of acitretin on spermatogenesis of rats. J Eur Acad Dermatol Venereol. 2006 Jul;20(6):689-92.

[3]Guilherme MDS, et, al. The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients. Front Aging Neurosci. 2019 Jul 23;11:182.

Acitretin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.06mL

0.61mL

0.31mL

15.32mL

3.06mL

1.53mL

30.64mL

6.13mL

3.06mL

Acitretin 技术信息

CAS号	55079-83-9
分子式	C₂₁H₂₆O₃
分子量	326.42

别名	阿曲汀 ;Ro 10-1670;all-trans Acitretin;Neotigason.;Soriatane;U0279;Ro 10-1670/000;Etretin
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解方案

细胞实验：

DMSO: 18 mg/mL(55.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00774852	Lupus Nephritis ... 展开 >> Lupus Erythematosus, Systemic 收起 <<	Phase 2	Completed	-	-
NCT02098213	Plaque Psoriasis	Phase 3	Recruiting	March 2019	France ... 展开 >> Station Thermale Avene Recruiting Avene, Languedoc-Rousillon, France, 34260 Principal Investigator: Didier DG GUERERO, Doctor Thermes de Molitg les bains Recruiting Molitg, Languedoc-Roussillon, France, 66500 Principal Investigator: Patrick PP POLFLIET, Doctor Thermes La Roche Posay Recruiting La Roche Posay, Poitou-Charentes, France, 86270 Principal Investigator: Asène AJ JELIASKOFF, Doctor Les thermes de ST-GERVAIS Recruiting Le Fayet, Rhône-Alpe, France, 74190 Principal Investigator: Radostina RB BACHVAROVA STOYANOVA, Doctor Etablissement thermal d'Uriage Recruiting Uriage, Rhône-Alpe, France, 38410 Principal Investigator: Murielle MB BOURGEOIS CLAVIER, Doctor 收起 <<
NCT00508547	-		Recruiting	September 30, 2029	-
NCT00774852	-		Completed	-	-
NCT01812954	-		Completed	-	-
NCT02644954	Psoriasis	Phase 3	Unknown	-	-
NCT02075697	-		Recruiting	October 2025	Spain ... 展开 >> Hospital Universitari German Trias y Pujol. Recruiting Badalona, Barcelona, Spain Fundación Hospital Alcorcón Recruiting Alcorcón, Madrid, Spain Hospital General Universitario de Alicante Recruiting Alicante, Spain Hospital Clinic Recruiting Barcelona, Spain Hospital del Mar. IMAS Recruiting Barcelona, Spain Hospital Universitario Reina Sofía Recruiting Córdoba, Spain Hospital Universitario de Gran Canaria Dr Negrín Recruiting Las Palmas, Spain Hospital Infanta Leonor Recruiting Madrid, Spain Hospital Universitario 12 de Octubre Recruiting Madrid, Spain Hospital Universitario de la Princesa Recruiting Madrid, Spain Hospital Clínico Universitario Virgen de la Victoria Recruiting Málaga, Spain Hospital Universitario Virgen Macarena de Sevilla Recruiting Sevilla, Spain Hospital General Universitario de Valencia Recruiting Valencia, Spain 收起 <<
NCT00353119	Palmoplantaris Pustulosis	Phase 3	Completed	-	Canada, Quebec ... 展开 >> Innovaderm Research Incorporated Laval, Quebec, Canada, H7S 2C6 Innovaderm Research Incorporated Montreal, Quebec, Canada, H2K 4L5 Canada Centre de Recherche Dermatologique du Québec métropolitain Quebec, Canada, G1V 4X7 收起 <<
NCT00629772	Palmoplantar Psoriasis	Phase 3	Completed	-	Canada, Ontario ... 展开 >> The Guenther Dermatology Research Center London, Ontario, Canada, N6A 3H7 Lynderm Research Inc. Markham, Ontario, Canada, L3P 1A8 Canada, Quebec Innovaderm Research Laval Laval, Quebec, Canada, H7S 2C6 Innovaderm Research Montreal, Quebec, Canada, H2K 4L5 Canada Centre de recherche dermatologique du Québec Métropolitain Quebec, Canada, G1V 4X7 收起 <<
NCT02330380	-		Completed	-	United States, Ohio ... 展开 >> University Hospitals Cleveland Medical Center Cleveland, Ohio, United States, 44106 收起 <<
NCT01706692	-		Recruiting	June 2021	Switzerland ... 展开 >> Aarau Cantonal Hospital Recruiting Aarau, Switzerland, CH-5001 Contact: Marcus Streit, Dr. med. 062 838 68 38 markus.streit@ksa.ch Principal Investigator: Marcus Streit, Dr. med. Basel University Hospital Recruiting Basel, Switzerland, CH-4031 Contact: Peter Itin, Prof. pitin@uhbs.ch Principal Investigator: Peter Itin, Prof. Inselspital - Bern University Hospital Recruiting Bern, Switzerland, CH-3001 Contact: Luca Borradori, Prof. Dr. 031 632 2111 Luca.Borradori@insel.ch Principal Investigator: Luca Borradori, Prof. Dr. Centre Hospitalier Universitaire Vaudois (CHUV) Recruiting Lausanne, Switzerland, CH-1011 Contact: Michel Gilliet, Prof. michel.gilliet@chuv.ch Principal Investigator: Curdin Conrad, PD Dr. med. St. Gallen Cantonal Hospital Recruiting St. Gallen, Switzerland, CH-9007 Contact: Damian Bühler, Dr. med. damian.buehler@kssg.ch Principal Investigator: Mark Anliker, Dr. med. Zurich University Hospital Recruiting Zurich, Switzerland, CH-8091 Contact: Alexander Navarini, Dr. alexander.navarini@usz.ch Principal Investigator: Lars French, Prof. 收起 <<
NCT00832364	Plaque Psoriasis	Phase 4	Withdrawn(Business decision. N... 展开 >>o patients were enrolled) 收起 <<	April 2010	United States, California ... 展开 >> UCSF - Dermatology Psoriasis & Skin Treatment Center San Francisco, California, United States, 94118 United States, Kentucky Physicians Skin Care Louisville, Kentucky, United States, 40217 United States, New York Mt. Sinai School of Medicine Department of Dermatology New York, New York, United States, 10029 收起 <<
NCT01761019	Psoriasis	Phase 4	Completed	-	United States, Pennsylvania ... 展开 >> UPMC Department of Dermatology, Falk Clinic Pittsburgh, Pennsylvania, United States, 15213 收起 <<
NCT01233583	-		Completed	-	United Kingdom ... 展开 >> Burnside House Aberdeen, United Kingdom, AB25 2ZR 收起 <<
NCT01761019	-		Completed	-	-
NCT00005660	-		Completed	-	United States, Maryland ... 展开 >> National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 收起 <<
NCT00644384	Non-melanomatous Skin Cancer	Not Applicable	Completed	-	-
NCT00395941	Psoriasis	Phase 2	Unknown	-	India ... 展开 >> PGIMER Not yet recruiting Chandigarh, India, 160012 Contact: Samir Malhotra, MD, DM +91-172-2755243 samirmalhotra345@yahoo.com Sub-Investigator: Promila Pandhi, MD,DM Principal Investigator: Samir Malhotra, MD, DM Sub-Investigator: Inderjeet Kaur, md Sub-Investigator: Sunil Dogra, MD 收起 <<
NCT03753867	HIV Infections	Phase 1	Not yet recruiting	May 8, 2019	-
NCT00002143	HIV Infections ... 展开 >> Psoriasis 收起 <<	Phase 3	Completed	-	United States, New York ... 展开 >> Beth Israel Med Ctr New York, New York, United States, 10003 收起 <<
NCT00003611	Non-melanomatous Skin Cancer	Not Applicable	Completed	-	United States, Arizona ... 展开 >> CCOP - Scottsdale Oncology Program Scottsdale, Arizona, United States, 85259-5404 United States, Florida Mayo Clinic Jacksonville, Florida, United States, 32224 United States, Illinois CCOP - Illinois Oncology Research Association Peoria, Illinois, United States, 61602 CCOP - Carle Cancer Center Urbana, Illinois, United States, 61801 United States, Iowa CCOP - Iowa Oncology Research Association Des Moines, Iowa, United States, 50309-1016 United States, Kansas CCOP - Wichita Wichita, Kansas, United States, 67214-3882 United States, Minnesota Mayo Clinic Cancer Center Rochester, Minnesota, United States, 55905 CentraCare Health Plaza Saint Cloud, Minnesota, United States, 56303 United States, North Dakota Medcenter One Health System Bismarck, North Dakota, United States, 58501 United States, South Dakota Rapid City Regional Hospital Rapid City, South Dakota, United States, 57709 CCOP - Sioux Community Cancer Consortium Sioux Falls, South Dakota, United States, 57104 收起 <<
NCT01094717	Psoriasis	Not Applicable	Terminated(lack of efficacy an... 展开 >>d lack of funding) 收起 <<	-	United States, Utah ... 展开 >> University of Utah Department of Dermatology Salt Lake City, Utah, United States, 84132 收起 <<
NCT02181790	Psoriasis, Skin or Nails	Phase 4	Terminated(Lack of subjects)	-	United States, New York ... 展开 >> Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 收起 <<
NCT02181790	-		Terminated(Lack of subjects)	-	-
NCT01078168	Alzheimer Disease	Phase 2	Completed	-	Germany ... 展开 >> Department of psychiatry and psychotherapy, University medical center of the Johannes Gutenberg-University Mainz Mainz, Rheinland-Pfalz, Germany, 55131 Universität Rostock Rostock, Germany, 18057 收起 <<
NCT00707070	Chronic Plaque Psoriasis	Phase 4	Unknown	October 2009	Italy ... 展开 >> Univeristy Hospital Not yet recruiting Verona, Italy, 37126 Contact: Paolo Gisondi, MD 45-812-2547 ext 0039 paolo.gisondi@univr.it Sub-Investigator: Micol Del Giglio, MD Sub-Investigator: Paolo Gisondi, MD Principal Investigator: Giampiero Girolomoni, Prof. 收起 <<
NCT01078168	-		Completed	-	-
NCT01443338	Psoriasis Vulgaris	Phase 4	Unknown	-	China, Zhejiang ... 展开 >> Second Affiliated Hospital, School of Medicine, Zhejiang University Recruiting Hangzhou, Zhejiang, China, 310009 Contact: Lunfei Liu, Md 86-571-87783743 liulunfei@medmail.com.cn Contact: Jisu Chen, MD 86-571-87783743 cgmcjs@msn.com Principal Investigator: Min Zheng, PHD&MD Sub-Investigator: Lunfei Liu, MD Sub-Investigator: JIsu Chen, MD Sub-Investigator: Jianliang Yan, MD Sub-Investigator: Jianyou Wang, MD 收起 <<
NCT00936065	Moderate to Severe Psoriasis	Phase 4	Completed	-	Korea, Republic of ... 展开 >> Pfizer Investigational Site Daejeon, Korea, Korea, Republic of, 301 721 Pfizer Investigational Site Gyeonggido, Korea, Korea, Republic of, 420 717 Pfizer Investigational Site Seoul, Korea, Korea, Republic of, 110 744 Pfizer Investigational Site Seoul, Korea, Korea, Republic of, 130 702 Pfizer Investigational Site Seoul, Korea, Korea, Republic of, 137 701 Pfizer Investigational Site Seoul, Korea, Korea, Republic of, 152 703 Pfizer Investigational Site S0, Seoul, Korea, Republic of, 137-701 Pfizer Investigational Site Seoul, Korea, Republic of, 135 710 Pfizer Investigational Site Seoul, Korea, Republic of, 138 736 Pfizer Investigational Site Seoul, Korea, Republic of, 431-070 收起 <<
NCT00936065	-		Completed	-	-
NCT00723437	Psoriasis	Phase 4	Completed	-	Italy ... 展开 >> Department of Dermatology University of Bologna Bologna, Italy, 40138 收起 <<
NCT02715960	Psoriasis Vulgaris	Phase 2	Unknown	December 2017	China, Hunan ... 展开 >> Xiangya Hospital Central South University Recruiting Changsha, Hunan, China, 410008 Contact: Yijing He, MD, PhD +86-1587481262 yijinghe@gmail.com 收起 <<
NCT00353119	-		Completed	-	-
NCT02191020	Psoriasis	Not Applicable	Completed	-	China, Shaanxi ... 展开 >> Xijing Hospitial Xi'an, Shaanxi, China, 710032 收起 <<
NCT01299220	Skin Rash	Phase 4	Withdrawn(Unable to enroll sub... 展开 >>jects by sponsor deadline) 收起 <<	September 2011	United States, Pennsylvania ... 展开 >> University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15213 收起 <<
NCT00488384	Carcinoma, Squamous Cell	Phase 4	Withdrawn(lack of subjects)	-	Switzerland ... 展开 >> Clinic for Dermatology University Hospital of Zurich Zurich, Switzerland 收起 <<
NCT00629772	-		Completed	-	-
NCT00156247	-		Completed	-	-
NCT00156247	Psoriasis	Phase 2	Completed	-	-
NCT01228409	Psoriasis	Phase 4	Unknown	-	United States, New York ... 展开 >> Mount Sinai Clinical Trials Recruiting New York, New York, United States, 10065 Contact: Giselle K Singer, MD 212-241-3288 Giselle.Singer@mssm.edu Principal Investigator: Amylynne J Frankel, MD 收起 <<
NCT02050321	Malignant Melanoma	Phase 2	Terminated(Pharmaceutical comp... 展开 >>any pulled support for the trial.) 收起 <<	-	United States, Arizona ... 展开 >> University of Arizona Cancer Center Tucson, Arizona, United States, 85724 收起 <<
NCT01039142	Psoriasis	Phase 4	Completed	-	India ... 展开 >> Post Graduate institute Of Medical Education and Research Chandigarh, India, 160012 收起 <<
NCT00811005	Pustular Palmoplantar Psoriasi... 展开 >>s 收起 <<	Phase 3	Unknown	October 2010	Austria ... 展开 >> Medical University of Vienna; University Clinic of Dermatology; Division of Special and Environmental Dermatology Vienna, Austria, 1180 收起 <<
NCT02050321	-		Terminated(Pharmaceutical comp... 展开 >>any pulled support for the trial.) 收起 <<	-	-
NCT01545284	Chronic Hand Dermatitis	Phase 2 Phase 3	Completed	-	Canada, Ontario ... 展开 >> Windsor Clinical Research Inc. Windsor, Ontario, Canada, N8W 5L7 Canada, Quebec Innovaderm Research Inc. Montreal, Quebec, Canada, H2K 4L5 收起 <<

阿维A /Acitretin {[allProObj[0].p_purity_real_show]}

Acitretin 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Acitretin 质控信息

Acitretin 生物活性

Acitretin 临床研究

Acitretin 参考文献

Acitretin 实验方案

Acitretin 技术信息

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阿维A /Acitretin {[allProObj[0].p_purity_real_show]}

Acitretin 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Acitretin 质控信息

Acitretin 生物活性

Acitretin 临床研究

Acitretin 参考文献

Acitretin 实验方案

Acitretin 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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