产品说明书

Acitretin

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Chemical Structure| 55079-83-9 同义名 : 阿曲汀 ;Ro 10-1670;all-trans Acitretin;Neotigason.;Soriatane;U0279;Ro 10-1670/000;Etretin
CAS号 : 55079-83-9
货号 : A470794
分子式 : C21H26O3
纯度 : 98%
分子量 : 326.42
MDL号 : MFCD00866632
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(55.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Acitretin (Ro 10-1670) is a second-generation systemic retinoid primarily utilized for treating psoriasis. It has also been explored for potential use in Alzheimer’s disease research[1].[2].[3].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00774852 Lupus Nephritis ... 展开 >> Lupus Erythematosus, Systemic 收起 << Phase 2 Completed - -
NCT02098213 Plaque Psoriasis Phase 3 Recruiting March 2019 France ... 展开 >> Station Thermale Avene Recruiting Avene, Languedoc-Rousillon, France, 34260 Principal Investigator: Didier DG GUERERO, Doctor          Thermes de Molitg les bains Recruiting Molitg, Languedoc-Roussillon, France, 66500 Principal Investigator: Patrick PP POLFLIET, Doctor          Thermes La Roche Posay Recruiting La Roche Posay, Poitou-Charentes, France, 86270 Principal Investigator: Asène AJ JELIASKOFF, Doctor          Les thermes de ST-GERVAIS Recruiting Le Fayet, Rhône-Alpe, France, 74190 Principal Investigator: Radostina RB BACHVAROVA STOYANOVA, Doctor          Etablissement thermal d'Uriage Recruiting Uriage, Rhône-Alpe, France, 38410 Principal Investigator: Murielle MB BOURGEOIS CLAVIER, Doctor 收起 <<
NCT00508547 - Recruiting September 30, 2029 -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.06mL

0.61mL

0.31mL

15.32mL

3.06mL

1.53mL

30.64mL

6.13mL

3.06mL
参考文献

[1]Lee CS, et al. A review of acitretin, a systemic retinoid for the treatment of psoriasis. Expert Opin Pharmacother. 2005 Aug;6(10):1725-34.

[2]Sengör B, et al. Effects of acitretin on spermatogenesis of rats. J Eur Acad Dermatol Venereol. 2006 Jul;20(6):689-92.

[3]Guilherme MDS, et, al. The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients. Front Aging Neurosci. 2019 Jul 23;11:182.