There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Avermectin B1 (Abamectin) consists of two chemically akin components of avermectin, serving as an oral anti-infective agent with applications in the study of parasitic worms, insect pests, and its use in agriculture and animal husbandry. This agent also promotes the generation of reactive oxygen species (ROS) and leads to cytotoxicity, apoptosis, and autophagy[1].[2].[4].
体内研究
Administered orally at a single dose of 0.2 mg/kg, Avermectin B1 proves highly effective against intestinal strongyles and Onchocerca microfilariae in horses[5].
体外研究
When applied at concentrations ranging from 0 to 80 μM for 12 hours, Avermectin B1 induces cytotoxic effects through the MAPK and ATM/ATR pathways in mouse embryonic fibroblast (MEF) cells and causes ROS-mediated DNA damage[1].
At a concentration of 36 μg/mL over 72 hours, it exhibits potent nematicidal effects on G. pallida in an aqueous solution, adversely affecting the viability and infectivity of G. pallida J2 in potato roots (cv. Spunta)[2].
Abamectin at 10 μM for 24 hours significantly induces cytotoxicity via ROS overproduction in haemocytes of Erocheir sinensis[3].
At 4 μM over 24 hours, Abamectin triggers apoptosis and autophagy by blocking ROS-mediated PI3K/AKT signaling in MGC803 cells[4].
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