Abamectin

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Chemical Structure| 71751-41-2 同义名 : 阿维菌素 B1
CAS号 : 71751-41-2
货号 : A1149915
分子式 : C95H142O28
纯度 : 96%
分子量 : 1732.127
MDL号 : MFCD28010814
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(144.33 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Avermectin B1 (Abamectin) consists of two chemically akin components of avermectin, serving as an oral anti-infective agent with applications in the study of parasitic worms, insect pests, and its use in agriculture and animal husbandry. This agent also promotes the generation of reactive oxygen species (ROS) and leads to cytotoxicity, apoptosis, and autophagy[1].[2].[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.58mL

0.12mL

0.06mL

2.89mL

0.58mL

0.29mL

5.77mL

1.15mL

0.58mL
参考文献

[1]Yiran Liang, et al. Abamectin induces cytotoxicity via the ROS, JNK, and ATM/ATR pathways. PLoS One. Environ Sci Pollut Res Int. 2020 Apr;27(12):13726-13734.

[2]Nicola Sasanelli, et al. Abamectin Efficacy on the Potato Cyst Nematode Globodera pallida. Plants (Basel). 2019 Dec 19;9(1):12.

[3]Yi Huang, et al. Cytotoxicity induced by abamectin exposure in haemocytes of Chinese mitten crab, Eriocheir sinensis. Environ Toxicol Pharmacol. 2020 Jul;77:103384.

[4]Shanshan Zhu, et al. Abamectin induces apoptosis and autophagy by inhibiting reactive oxygen species-mediated PI3K/AKT signaling in MGC803 cells. J Biochem Mol Toxicol. 2019 Jul;33(7):e22336.

[5]Mogg TD, et al. Efficacy of avermectin B1 given orally against equine intestinal strongyles and Onchocera microfilaria. Aust Vet J. 1990 Nov;67(11):399-401.