规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50μL*10mM(DMSO) | ¥99随货¥69 | 咨询 | |
100μL*10mM(DMSO) | ¥109随货¥79 | 咨询 | |
250μL*10mM(DMSO) | ¥229随货¥169 | 咨询 | |
500μL*10mM(DMSO) | ¥299随货¥209 | 咨询 | |
10mM*1mL(DMSO) | ¥438 | 咨询 | |
1mg | ¥261 | 咨询 | |
5mg | ¥595 | 咨询 | |
10mg | ¥952 | 咨询 | |
25mg | ¥1750 | 咨询 | |
50mg | ¥2800 | 咨询 | |
100mg | ¥3920 | 咨询 |
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描述 | AZD-2098 is a selective CCR4 receptor antagonist with pIC50 value of 7.8. It is a candidate drug for asthma indications. AZD-2098 inhibited the cellular responses mediated by the hCCR4 receptor with pIC50 values of 7.5, 6.3 and 6.3 for inhibition of CCL22 Ca2+ response (measured by MDC-induced Ca2+ flux in CHO cells transfected with the human CCR4 receptor), inhibition of Th2 cell CCL22 driven chemotaxis in 0.3% HAS (measured by MDC-induced chemotaxis) and inhibition of Th2 cell CCL17 driven chemotaxis in 0.3% HAS (measured by TARC-induced chemotaxis). Oral administration of AZD-2098 at dose>0.75µmol/kg 1 hour prior to antigen challenge (then every 12 hours thereafter prior to termination 96 hours post challenge) reduced alveolitis and leukocyte trafficking in the microvasculature of sensitized rats. |
计算器 | ||||
存储液制备 | ![]() | 1mg | 5mg | 10mg |
1 mM 5 mM 10 mM | 2.99mL 0.60mL 0.30mL | 14.96mL 2.99mL 1.50mL | 29.92mL 5.98mL 2.99mL |
CAS号 | 566203-88-1 |
分子式 | C11H9Cl2N3O3S |
分子量 | 334.178 |
别名 | |
运输 | 蓝冰 |
存储条件 | In solvent -20°C:3-6个月-80°C:12个月 Pure form Keep in dark place,Inert atmosphere,Room temperature |
溶解方案 | DMSO: 105 mg/mL(314.2 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 无水乙醇: 5 mg/mL(14.96 mM),配合低频超声,并水浴加热至45℃助溶,注意:无水乙醇开封后,易挥发,也会吸收空气中的水分,导致溶解能力下降,请避免使用开封较久的乙醇 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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动物实验配方 |