AY 9944 2HCl is an inhibitor of hedgehog (Hh) signaling.
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HazMat fee for 500 gram (Estimated)
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AY 9944 is a specific cholesterol biosynthesis inhibitor that inhibits 7-dehydrocholesterol Δ7 reductase (DHCR7) with an IC50 of 13 nM. AY 9944 causes hypocholesterolaemia and accumulation of 7DHC. At high doses, AY 9944 also inhibits the sterol Δ7-Δ8 isomerase in cultured embryos, leading to the accumulation of cholesterol-8-en-3β-ol[1][2][3].AY 9944 affects the type of free sterols in keratinocytes at a concentration of 1 µg/ml for 15 h. AY 9944 inhibits the synthesis of cholesterol and desmosterol, but increases the synthesis of 7-dehydrocholesterol and oleanol[2].
AY 9944 动物研究
Animal study
At a dose of 7.5 mg/kg, administered every 6 days from postnatal day 2 to postnatal day 20, i.h., AY 9944 reduced brain cholesterol in Long-Evans hooded rats until 400 days after cessation of treatment. Brain cholesterol was reduced and 7-dehydrocholesterol was elevated in all brain regions of the rats, and AY 9944 had more severe effects on changes in plasma and liver steroids in female rats[3].
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