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AY 9944 {[allProObj[0].p_purity_real_show]}

货号：A758319 同义名： AY 9944 dihydrochloride Ambeed 开学季，买赠积分，赢豪礼

AY 9944 2HCl is an inhibitor of hedgehog (Hh) signaling.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
AY 9944 化学结构 CAS号：366-93-8
AY 9944 化学结构
CAS号：366-93-8
AY 9944 3D分子结构
CAS号：366-93-8
AY 9944 化学结构 CAS号：366-93-8
AY 9944 3D分子结构 CAS号：366-93-8
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AY 9944 纯度/质量文件 产品仅供科研

货号：A758319 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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AY 9944 生物活性

描述 AY 9944 is a specific cholesterol biosynthesis inhibitor that inhibits 7-dehydrocholesterol Δ7 reductase (DHCR7) with an IC50 of 13 nM. AY 9944 causes hypocholesterolaemia and accumulation of 7DHC. At high doses, AY 9944 also inhibits the sterol Δ7-Δ8 isomerase in cultured embryos, leading to the accumulation of cholesterol-8-en-3β-ol[1][2][3].AY 9944 affects the type of free sterols in keratinocytes at a concentration of 1 µg/ml for 15 h. AY 9944 inhibits the synthesis of cholesterol and desmosterol, but increases the synthesis of 7-dehydrocholesterol and oleanol[2].

AY 9944 动物研究

Animal study At a dose of 7.5 mg/kg, administered every 6 days from postnatal day 2 to postnatal day 20, i.h., AY 9944 reduced brain cholesterol in Long-Evans hooded rats until 400 days after cessation of treatment. Brain cholesterol was reduced and 7-dehydrocholesterol was elevated in all brain regions of the rats, and AY 9944 had more severe effects on changes in plasma and liver steroids in female rats[3].

AY 9944 参考文献

[1]Moebius FF, et al. Molecular cloning and expression of the human delta7-sterol reductase. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1899-902.

[2]Nemanic MK, et al. In vitro synthesis of vitamin D-3 by cultured human keratinocytes and fibroblasts: action spectrum and effect of AY-9944. Biochim Biophys Acta. 1985 Sep 6;841(3):267-77.

[3]Cortez MA, et al. Brain sterols in the AY-9944 rat model of atypical absence seizures. Epilepsia. 2002 Jan;43(1):3-8.

AY 9944 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.15mL

0.43mL

0.22mL

10.77mL

2.15mL

1.08mL

21.54mL

4.31mL

2.15mL

AY 9944 技术信息

CAS号366-93-8
分子式C22H30Cl4N2
分子量 464.299
别名 AY 9944 dihydrochloride
运输蓝冰
存储条件

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 4 mg/mL(8.62 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 5 mg/mL(10.77 mM)，配合低频超声助溶
动物实验配方

Tags: AY 9944 | 366-93-8 | AY9944 | AY-9944 | DHCR7 Inhibitor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | AY 9944 纯度/质量文件 | AY 9944 生物活性 | AY 9944 参考文献 | AY 9944 实验方案 | AY 9944 技术信息

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