货号:A192734 同义名: Adenylylmethylenediphosphonate disodium salt
AMP-PCP disodium是一种 ATP 类似物,通过结合 Hsp90 的 N 末端结构域促进同型二聚体形成,广泛用于分子伴侣的研究。
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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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描述 | AMP-PCP disodium is an ATP analogue that binds to the N-terminal structural domain of Hsp90 with a Kd value of 3.8 μM. Binding to AMP-PCP disodium facilitates the formation of an active homodimer of Hsp90 [1].Binding to AMP-PCP disodium favours the formation of Hsp90 active homodimers because AMP-PCP disodium enhances the slow-motion conformational changes of lid segment (A117-A141) and surrounding region residues (A111-G135). A total of 170 non-proline residues were identified by the triple-labelled Hsp90 bound to AMP-PCP disodium[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.81mL 0.36mL 0.18mL |
9.07mL 1.81mL 0.91mL |
18.14mL 3.63mL 1.81mL |
CAS号 | 7414-56-4 |
分子式 | C11H18N5Na2O12P3 |
分子量 | 551.188 |
别名 | Adenylylmethylenediphosphonate disodium salt |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
H2O: 100 mg/mL(181.43 mM),配合低频超声助溶 |
动物实验配方 |