货号：A192734同义名：
Adenylylmethylenediphosphonate disodium salt
AMP-PCP disodium是一种 ATP 类似物，通过结合 Hsp90 的 N 末端结构域促进同型二聚体形成，广泛用于分子伴侣的研究。
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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
AMP-PCP disodium is an ATP analogue that binds to the N-terminal structural domain of Hsp90 with a Kd value of 3.8 μM. Binding to AMP-PCP disodium facilitates the formation of an active homodimer of Hsp90 [1].Binding to AMP-PCP disodium favours the formation of Hsp90 active homodimers because AMP-PCP disodium enhances the slow-motion conformational changes of lid segment (A117-A141) and surrounding region residues (A111-G135). A total of 170 non-proline residues were identified by the triple-labelled Hsp90 bound to AMP-PCP disodium[1].
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