产品说明书

AMP-PCP disodium

Print
Chemical Structure| 7414-56-4 同义名 : Adenylylmethylenediphosphonate disodium salt
CAS号 : 7414-56-4
货号 : A192734
分子式 : C11H18N5Na2O12P3
纯度 : 97%
分子量 : 551.188
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 100 mg/mL(181.43 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 AMP-PCP disodium is an ATP analogue that binds to the N-terminal structural domain of Hsp90 with a Kd value of 3.8 μM. Binding to AMP-PCP disodium facilitates the formation of an active homodimer of Hsp90 [1].Binding to AMP-PCP disodium favours the formation of Hsp90 active homodimers because AMP-PCP disodium enhances the slow-motion conformational changes of lid segment (A117-A141) and surrounding region residues (A111-G135). A total of 170 non-proline residues were identified by the triple-labelled Hsp90 bound to AMP-PCP disodium[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.81mL

0.36mL

0.18mL

9.07mL

1.81mL

0.91mL

18.14mL

3.63mL

1.81mL
参考文献

[1]Zhang H, et al. A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain. Sci Rep. 2015 Apr 13;5:9542.