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AM580

货号:A184890 同义名: CD336;Ro 40-6055

AM580是一种稳定的视黄酸苯甲酸衍生物,作为 RARα 的激动剂。

AM580 化学结构 CAS号:102121-60-8
AM580 化学结构
CAS号:102121-60-8
AM580 3D分子结构
CAS号:102121-60-8
AM580 化学结构 CAS号:102121-60-8
AM580 3D分子结构 CAS号:102121-60-8
规格 价格 库存 数量
100μL*10mM(DMSO) ¥109 咨询
250μL*10mM(DMSO) ¥229 咨询
500μL*10mM(DMSO) ¥299 咨询
10mM*1mL(DMSO) ¥462 咨询
1mg ¥171 咨询
5mg ¥378 咨询
10mg ¥567 咨询
25mg ¥1276 咨询
50mg ¥2169 咨询
100mg ¥3458 咨询
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AM580 纯度/质量文件 产品仅供科研

货号:A184890 标准纯度:
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AM580 生物活性

描述 AM580 is a retinoic acid analog, working as a selective RARα agonist with EC50 values of 0.3, 8.6 and 13 nM for RARα, RARβ and RARγ respectively. AM580 at concentration of 100nM could recapitulate all of the T cell activation and type 2 cytokine-inducing effects of ATRA and 9-cis-RA on promotion of IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-γ and TNF-α expression by activated human T cells and reduces the synthesis of IL-12p70 from accessory cells. Enhancing RA signaling by AM580 at concentration of 10nM profoundly promoted reprogramming of MEFs with transfected with four transcription factors (Oct4, Sox2, c-Myc, and Klf4), shown as substantial increase of the number of AP+ iPSC colonies.

AM580 动物研究

Dose Mice: 3.75 mg/kg[3] (i.p.), 2 mg/kg - 10 mg/kg[4] (i.p.), 12.5 mg/kg (i.p.); 0.3 mg/kg[1] (p.o., in diet), 0.6 mg/kg - 0.8 mg/kg[5] (p.o., in drinking water)
Administration i.p., p.o.
Pharmacokinetics
Animal Rats[4]
Dose 10 mg/kg
Administration i.p.
Vd 1.5 ± 0.7 L/kg
T1/2 1.7 ± 0.3 h
Tmax 0.6 ± 0.4 h
CL 9.7 ± 3.2 ml/min/kg
Cmax 5.8 ± 2.1 μg/ml
AUC 18.4 ± 5.4 μg·h/ml

AM580 参考文献

[1]Lu Y, Bertran S, et al. Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARalpha agonist AM580. Oncogene. 2010 Jun 24;29(25):3665-76.

[2]Gianni M, Li Calzi M, et al. AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood. 1996 Feb 15;87(4):1520-31.

[3]Nishikiori N, Osanai M, et al. Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains. Invest Ophthalmol Vis Sci. 2007 May;48(5):2224-9.

[4]Dimitrova B, Caccia S, et al. Determination of the retinobenzoic acid derivative Am580 in rat plasma by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1995 May 19;667(2):301-6.

[5]Melis M, Tang XH, et al. Effects of AM80 compared to AC261066 in a high fat diet mouse model of liver disease. PLoS One. 2019 Jan 24;14(1):e0211071.

AM580 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.85mL

0.57mL

0.28mL

14.23mL

2.85mL

1.42mL

28.45mL

5.69mL

2.85mL

AM580 技术信息

CAS号102121-60-8
分子式C22H25NO3
分子量 351.439
别名 CD336;Ro 40-6055;NSC608001
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Store in freezer, under -20°C

溶解度

DMSO: 45 mg/mL(128.05 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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