AM580
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货号：A184890
同义名：
CD336;Ro 40-6055
AM580 是一种稳定的视黄酸苯甲酸衍生物，作为 RARα 的激动剂。
AM580 化学结构
AM580 3D分子结构
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AM580 纯度/质量文件 产品仅供科研
货号：A184890
标准纯度：
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产品说明书
全球学术期刊中引用的产品
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• PLoS Biol. , 2025, 23(2): e3002961. Ambeed. A181909
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• Redox Rep. , 2025, 30(1): 2454887. Ambeed. A1155014
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AM580 质控信息
AM580 生物活性
描述
AM580 is a retinoic acid analog, working as a selective RARα agonist with EC50 values of 0.3, 8.6 and 13 nM for RARα, RARβ and RARγ respectively. AM580 at concentration of 100nM could recapitulate all of the T cell activation and type 2 cytokine-inducing effects of ATRA and 9-cis-RA on promotion of IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-γ and TNF-α expression by activated human T cells and reduces the synthesis of IL-12p70 from accessory cells. Enhancing RA signaling by AM580 at concentration of 10nM profoundly promoted reprogramming of MEFs with transfected with four transcription factors (Oct4, Sox2, c-Myc, and Klf4), shown as substantial increase of the number of AP+ iPSC colonies.
AM580 动物研究
Dose
Mice: 3.75 mg/kg[3] [4] [1] [5]
Administration
i.p., p.o.
Pharmacokinetics
Animal
Rats[4]
Dose
10 mg/kg
Administration
i.p.
Vd
1.5 ± 0.7 L/kg
T1/2
1.7 ± 0.3 h
Tmax
0.6 ± 0.4 h
CL
9.7 ± 3.2 ml/min/kg
Cmax
5.8 ± 2.1 μg/ml
AUC
18.4 ± 5.4 μg·h/ml
AM580 参考文献
[1] Lu Y, Bertran S, et al. Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARalpha agonist AM580. Oncogene. 2010 Jun 24;29(25):3665-76.
[2] Gianni M, Li Calzi M, et al. AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood. 1996 Feb 15;87(4):1520-31.
[3] Nishikiori N, Osanai M, et al. Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains. Invest Ophthalmol Vis Sci. 2007 May;48(5):2224-9.
[4] Dimitrova B, Caccia S, et al. Determination of the retinobenzoic acid derivative Am580 in rat plasma by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1995 May 19;667(2):301-6.
[5] Melis M, Tang XH, et al. Effects of AM80 compared to AC261066 in a high fat diet mouse model of liver disease. PLoS One. 2019 Jan 24;14(1):e0211071.
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AM580 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.85mL
0.57mL
0.28mL
14.23mL
2.85mL
1.42mL
28.45mL
5.69mL
2.85mL
AM580 技术信息
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