7-Epitaxol is a natural product isolated and purified from the barks of Taxus chinensis (Pilger) Rehd. which is the major derivative of taxol found in cells and that its presence does not alter, in a major way, the overall biological activity of taxol.
7-Epitaxol, as an anticancer drug, can promote tubulin polymerization and stabilize microtubules from depolymerizing[3].In vivo, administration of 7-Epitaxol over four cumulative doses at 2 mg/kg induced terminal arbor degeneration (TAD) in only the intraepidermal DRG axons of ratsLisse TS, Elias LJ, Pellegrini AD, Martin PB, Spaulding EL, Lopes O, Brochu EA, Carter EV, Waldron A, Rieger S. Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):E2189-98. doi: 10.1073/pnas.1525096113. Epub 2016 Mar 28. PMID: 27035978; PMCID: PMC4839466.https://pubmed.ncbi.nlm.nih.gov/27035978/. In vitro, 7-Epitaxoll treated(30 μm) PC1/3 KD macrophages secreted additional antitumoral factors active against glioma cells[4].
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