产品说明书
7-epi-Taxol
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同义名 : | 7-epi-Paclitaxel |
| CAS号 : | 105454-04-4 | |
| 货号 : | A495321 | |
| 分子式 : | C47H51NO14 | |
| 纯度 : | 98% | |
| 分子量 : | 853.906 | |
| MDL号 : | MFCD07783713 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(122.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 7-Epitaxol, as an anticancer drug, can promote tubulin polymerization and stabilize microtubules from depolymerizing[3].In vivo, administration of 7-Epitaxol over four cumulative doses at 2 mg/kg induced terminal arbor degeneration (TAD) in only the intraepidermal DRG axons of ratsLisse TS, Elias LJ, Pellegrini AD, Martin PB, Spaulding EL, Lopes O, Brochu EA, Carter EV, Waldron A, Rieger S. Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):E2189-98. doi: 10.1073/pnas.1525096113. Epub 2016 Mar 28. PMID: 27035978; PMCID: PMC4839466.https://pubmed.ncbi.nlm.nih.gov/27035978/. In vitro, 7-Epitaxoll treated(30 μm) PC1/3 KD macrophages secreted additional antitumoral factors active against glioma cells[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.17mL 0.23mL 0.12mL |
5.86mL 1.17mL 0.59mL |
11.71mL 2.34mL 1.17mL |
| 参考文献 |
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