7,8-Dihydroxyflavone (7,8-DHF) is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). 7,8-DHF (500 nM) protected primary neurons from Aβ-induced toxicity and promoted dendrite branching and synaptogenesis. Chronic oral administration of 7,8-DHF activated TrkB signaling and prevented Aβ deposition in transgenic mice that coexpress five familial Alzheimer's disease mutations (5XFAD mice). Moreover, 7,8-DHF inhibited the loss of hippocampal synapses, restored synapse number and synaptic plasticity, and prevented memory deficits[3]. 7,8-DHF activated the Nrf2 signaling pathway in primary chondrocytes[4]. 7,8-DHF might be capable of alleviating the jejunal contractile damage caused by IR (ischaemia-reperfusion) through activation of TrkB and augmentation of M3 expression[5]. 7,8-DHF (5 mg/kg; i.p.) administration conferred beneficial effects against alcohol and HFD-induced memory deficit via its unique antioxidant, anti-inflammatory, anti-apoptotic potential, along with the activation of TrkB/BDNF signaling pathway in the hippocampus[6].
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