产品说明书
7,8-Dihydroxyflavone
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同义名 : | 二羟基黄酮水合物 ;7,8-DHF |
| CAS号 : | 38183-03-8 | |
| 货号 : | A362609 | |
| 分子式 : | C15H10O4 | |
| 纯度 : | 97% | |
| 分子量 : | 254.24 | |
| MDL号 : | MFCD00006836 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(413 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | 7,8-Dihydroxyflavone (7,8-DHF) is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). 7,8-DHF (500 nM) protected primary neurons from Aβ-induced toxicity and promoted dendrite branching and synaptogenesis. Chronic oral administration of 7,8-DHF activated TrkB signaling and prevented Aβ deposition in transgenic mice that coexpress five familial Alzheimer's disease mutations (5XFAD mice). Moreover, 7,8-DHF inhibited the loss of hippocampal synapses, restored synapse number and synaptic plasticity, and prevented memory deficits[3]. 7,8-DHF activated the Nrf2 signaling pathway in primary chondrocytes[4]. 7,8-DHF might be capable of alleviating the jejunal contractile damage caused by IR (ischaemia-reperfusion) through activation of TrkB and augmentation of M3 expression[5]. 7,8-DHF (5 mg/kg; i.p.) administration conferred beneficial effects against alcohol and HFD-induced memory deficit via its unique antioxidant, anti-inflammatory, anti-apoptotic potential, along with the activation of TrkB/BDNF signaling pathway in the hippocampus[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.93mL 0.79mL 0.39mL |
19.67mL 3.93mL 1.97mL |
39.33mL 7.87mL 3.93mL |
| 参考文献 |
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