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/ 6-Aminocaproic acid

6-氨基己酸 /6-Aminocaproic acid {[allProObj[0].p_purity_real_show]}

货号：A449367 同义名： 氨基己酸 / EACA;Epsilon-Amino-n-caproic Acid

6-Aminocaproic Acid inhibits the plasmin activating enzymes streptokinase, fibrinokinase and urokinase, it is an antifibrinolytic agent.

6-Aminocaproic acid 化学结构 CAS号：60-32-2
6-Aminocaproic acid 化学结构
CAS号：60-32-2
6-Aminocaproic acid 3D分子结构
CAS号：60-32-2
6-Aminocaproic acid 化学结构 CAS号：60-32-2
6-Aminocaproic acid 3D分子结构 CAS号：60-32-2
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6-Aminocaproic acid 纯度/质量文件 产品仅供科研

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6-Aminocaproic acid 生物活性

描述 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, acts as a potent oral inhibitor of plasmin and plasminogen. It serves as a powerful antifibrinolytic agent by preventing clot lysis through competitive binding to lysine residues on plasminogen, inhibiting plasmin formation, and thereby reducing fibrinolysis. This compound is researched for use in treating bleeding disorders[1].[2].
体内研究

Furthermore, 6-Aminocaproic acid administered orally in doses ranging from 20 to 100 mg/kg inhibits fibrinolysis in dogs across all doses tested. It is rapidly absorbed with a Tmax of approximately 1 hour and is quickly eliminated, indicating its fast-acting nature in clinical applications[3].

体外研究

In studies involving Asian elephants, 6-Aminocaproic acid at concentrations between 20 to 180 μg/mL effectively inhibits fibrinolysis in plasma, with an effective concentration of 61.5 μg/mL[2].

It is also employed as a hydrophobic linker to enhance the efficacy of PEGylated indocyanine green for applications in near-infrared fluorescence imaging and photothermal cancer therapy[4].

6-Aminocaproic acid 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01968070 Healthy Volunteers Phase 1 Completed - United States, Indiana ... 展开 >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Evansville, Indiana, United States, 47710 收起 <<
NCT03364491 Obstetrical Complications ... 展开 >> Hemorrhage Labor and Delivery 收起 << Phase 3 Recruiting December 2020 United States, Alabama ... 展开 >> University of Alabama - Birmingham Recruiting Birmingham, Alabama, United States, 35233 Contact: Stacy Harris, BSN    205-996-6262    stacylharris@uabmc.edu    Principal Investigator: Alan TN Tita, MD          United States, Illinois Northwestern University-Prentice Hospital Recruiting Chicago, Illinois, United States, 60611 Contact: Gail Mallett, RN BSN CCRC    312-503-3200    g-mallett@northwestern.edu    Principal Investigator: William Grobman, MD          United States, New York Columbia University Recruiting New York, New York, United States, 10032 Contact: Sabine Bousleiman    212-305-4348    sb1080@columbia.edu    Principal Investigator: Cynthia Gyamfi-Bannerman, MD          United States, North Carolina University of North Carolina - Chapel Hill Recruiting Chapel Hill, North Carolina, United States, 27599 Contact: Kelly Clark, RN    919-350-6117    kelly_clark@med.unc.edu    Principal Investigator: John M Thorp, Jr., MD          United States, Ohio Case Western Reserve-MetroHealth Recruiting Cleveland, Ohio, United States, 44109 Contact: Wendy Dalton, RN    216-778-7533    wdalton@metrohealth.org    Principal Investigator: Edward Chien, MD          Ohio State University Hospital Recruiting Columbus, Ohio, United States, 43210 Contact: Anna Bartholomew, RN, BSN    614-685-3229    anna.bartholomew@osumc.edu    Principal Investigator: Catalin S Buhimschi, MD          United States, Pennsylvania Hospital of the University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Jennifer Craig, BSN    212-662-3926    jennifer.craig@uphs.upenn.edu    Principal Investigator: Samuel Parry, MD          Magee Women's Hospital of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: Melissa Bickus, BS, RN    412-641-4072    mbickus@mail.magee.edu    Principal Investigator: Hyagriv Simhan, MD, MS          United States, Rhode Island Brown University Recruiting Providence, Rhode Island, United States, 02905 Contact: Donna Allard, RNC    401-274-1122    dallard@wihri.org    Principal Investigator: Dwight J Rouse, MD          United States, Texas University of Texas Medical Branch Recruiting Galveston, Texas, United States, 77555 Contact: Ashley Salazar, MSN    409-772-0312    assalaza@utmb.edu    Principal Investigator: George R Saade, MD          University of Texas - Houston Recruiting Houston, Texas, United States, 77030 Contact: Felecia Ortiz, RN BSN    713-500-6467    Felecia.Ortiz@uth.tmc.edu    Principal Investigator: Suneet Chauhan, MD          United States, Utah University of Utah Medical Center Recruiting Salt Lake City, Utah, United States, 84132 Contact: Kim Hill, RN    801-585-7645    Kim.Hill@hsc.utah.edu    Principal Investigator: Michael W Varner, MD 收起 <<
NCT01428713 Menorrhagia Not Applicable Completed - United States, Texas ... 展开 >> Baylor College of Medicine Houston, Texas, United States, 77030 收起 <<

6-Aminocaproic acid 参考文献

[1]Griffin JD, et, al. Epsilon-aminocaproic acid (EACA). Semin Thromb Hemost. Summer 1978;5(1):27-40.

[2]Kaye S, et, al. EFFECT OF ε-AMINOCAPROIC ACID ON FIBRINOLYSIS IN PLASMA OF ASIAN ELEPHANTS (ELEPHAS MAXIMUS). J Zoo Wildl Med. 2016 Jun;47(2):397-404.

[3]Brown JC, et, al. Effect of aminocaproic acid on clot strength and clot lysis of canine blood determined by use of an in vitro model of hyperfibrinolysis. Am J Vet Res. 2016 Nov;77(11):1258-1265.

[4]Hu Q, et al. 6-Aminocaproic acid as a linker to improve near-infrared fluorescence imaging and photothermal cancer therapy of PEGylated indocyanine green. Colloids Surf B Biointerfaces. 2021 Jan;197:111372.

6-Aminocaproic acid 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

7.62mL

1.52mL

0.76mL

38.12mL

7.62mL

3.81mL

76.24mL

15.25mL

7.62mL

6-Aminocaproic acid 技术信息

CAS号60-32-2
分子式C6H13NO2
分子量 131.173
别名 氨基己酸 ;EACA;Epsilon-Amino-n-caproic Acid;Hepin;Capracid;Aminocaproic acid;NSC 400230;NSC 212532;NSC 26154;ε-Aminocaproic Acid;(6-)ε-​Aminocaproic acid;6-Aminohexanoic acid
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Room Temperature
溶解度

H2O: 50 mg/mL(381.18 mM)
动物实验配方

Tags: 6-Aminocaproic acid | EACA;Epsilon-Amino-n-caproic Acid;Hepin;Capracid;Aminocaproic acid;NSC 400230;NSC 212532;NSC 26154;ε-Aminocaproic Acid;(6-)ε-​Aminocaproic acid;6-Aminohexanoic acid | 氨基己酸 | Hybridization Reagent | Bile Acid | AmBeed-信号通路专用抑制剂 | 6-Aminocaproic acid 纯度/质量文件 | 6-Aminocaproic acid 生物活性 | 6-Aminocaproic acid 临床数据 | 6-Aminocaproic acid 参考文献 | 6-Aminocaproic acid 实验方案 | 6-Aminocaproic acid 技术信息

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