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5-羟色氨 /5-Hydroxytryptophan {[allProObj[0].p_purity_real_show]}

货号：A206092 同义名： 5-羟基色氨酸 / DL-5-Hydroxytryptophan;5-HTP

5-Hydroxytryptophan is a naturally occurring amino acid which acts as a chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
5-Hydroxytryptophan 化学结构 CAS号：56-69-9
5-Hydroxytryptophan 化学结构
CAS号：56-69-9
5-Hydroxytryptophan 3D分子结构
CAS号：56-69-9
5-Hydroxytryptophan 化学结构 CAS号：56-69-9
5-Hydroxytryptophan 3D分子结构 CAS号：56-69-9
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5-Hydroxytryptophan 纯度/质量文件 产品仅供科研

货号：A206092 标准纯度： {[allProObj[0].p_purity_real_show]}
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5-Hydroxytryptophan 生物活性

描述 5-Hydroxytryptophan(5-HTP) is a kind of natural amino acid and dietary supplement used as antidepressant, appetite inhibitor and sleep assistant. It is the precursor of neurotransmitter serotonin and the antagonist of reserpine[3].5-HTP treatment (10-3 - 10-2 M) significantly inhibited cell proliferation through blocking of the S-phase of the cell cycle and increasing apoptotic and necrotic cell death[4]. Moreover, 4h after 5-HTP administrations, the endogenous serotonin levels increased by fourfold (150mg/kg) in the plasma and brain associated with profound hyperthermia (+3.86±0.24°C, oxidative stress and NO upregulation[5].

5-Hydroxytryptophan 动物研究

Animal study 抑郁症[6]
动物：Wistar大鼠，雄性，150-200 g。
给药：50 mg/kg，腹腔注射。

5-Hydroxytryptophan 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02064309 Long-standing Type 1 Diabetes ... 展开 >>Mellitus 收起 << Phase 1 Phase 2 Active, not recruiting May 2019 Sweden ... 展开 >> Uppsala University Hospital Uppsala, Sweden, SE-75123 收起 <<
NCT02509143 Postoperative Nausea and Vomit... 展开 >>ing Colorectal Neoplasms 收起 << Not Applicable Completed - Korea, Republic of ... 展开 >> National Clinical Research Center, Korean Medicine Hospital, Pusan National University Yangsan, Kyung Sang South Province, Korea, Republic of, 626-770 Pusan National University Yangsan Hospital Yangsan, Kyung Sang South Province, Korea, Republic of, 626-770 收起 <<
NCT03364101 Sleep Not Applicable Completed - United States, New York ... 展开 >> New York University School of Medicine New York, New York, United States, 10016 收起 <<

5-Hydroxytryptophan 参考文献

[1]Shaw K, Turner J, Del Mar C. Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database Syst Rev. 2002;(1):CD003198.

[2]Birdsall TC. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev. 1998 Aug;3(4):271-80.

[3]CARLSSON A, LINDQVIST M, MAGNUSSON T. 3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists. Nature. 1957 Nov 30;180(4596):1200. doi: 10.1038/1801200a0. PMID: 13483658.

[4]Gordeeva O, Safandeev V. 5-Hydroxytryptophan (5-HTP)-induced intracellular syndrome in mouse non-neural embryonic cells is associated with inhibited proliferation and cell death. Neuropharmacology. 2021 Sep 1;195:107862. doi: 10.1016/j.neuropharm.2019.107862. Epub 2019 Nov 25. PMID: 31778690.

[5]Sharma A, Castellani RJ, Smith MA, Muresanu DF, Dey PK, Sharma HS. 5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology. Int Rev Neurobiol. 2019;146:1-44. doi: 10.1016/bs.irn.2019.06.005. Epub 2019 Jul 18. PMID: 31349924.

[6]Hingtgen JN, Fuller RW, Mason NR, Aprison MH. Blockade of a 5-hydroxytryptophan-induced animal model of depression with a potent and selective 5-HT2 receptor antagonist (LY53857). Biol Psychiatry. 1985 Jun;20(6):592-7.

5-Hydroxytryptophan 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.54mL

0.91mL

0.45mL

22.70mL

4.54mL

2.27mL

45.41mL

9.08mL

4.54mL

5-Hydroxytryptophan 技术信息

CAS号56-69-9
分子式C11H12N2O3
分子量 220.225
别名 5-羟基色氨酸 ;DL-5-Hydroxytryptophan;5-HTP;NSC-92523
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 85 mg/mL(385.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 12 mg/mL(54.49 mM)，配合低频超声助溶
动物实验配方

Tags: 5-Hydroxytryptophan | 56-69-9 | 5-HTP | DL-5-Hydroxytryptophan | Metabolic Enzyme/Protease | Endogenous Metabolite | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | 5-Hydroxytryptophan 纯度/质量文件 | 5-Hydroxytryptophan 生物活性 | 5-Hydroxytryptophan 临床数据 | 5-Hydroxytryptophan 参考文献 | 5-Hydroxytryptophan 实验方案 | 5-Hydroxytryptophan 技术信息

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