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5'-氟二异丁酮肟 /5'-Fluoroindirubinoxime {[allProObj[0].p_purity_real_show]}

货号:A929501 同义名: 5'-FIO;PD 082106 Ambeed 开学季,买赠积分,赢豪礼

5'-Fluoroindirubinoxime is an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) with IC50 of 15 nM.

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Type HazMat fee for 500 gram (Estimated)
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Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
5'-Fluoroindirubinoxime 化学结构 CAS号:861214-33-7
5'-Fluoroindirubinoxime 化学结构
CAS号:861214-33-7
5'-Fluoroindirubinoxime 3D分子结构
CAS号:861214-33-7
5'-Fluoroindirubinoxime 化学结构 CAS号:861214-33-7
5'-Fluoroindirubinoxime 3D分子结构 CAS号:861214-33-7
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5'-Fluoroindirubinoxime 纯度/质量文件 产品仅供科研

货号:A929501 标准纯度: {[allProObj[0].p_purity_real_show]}
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FLT3 (ITD), IC50: 1.1 nM

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FLT3, IC50: 0.29 nM

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Amuvatinib +

FLT3 (D835Y), IC50: 81 nM

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Pacritinib ++

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{[allProObj[0].p_purity_real_show]}
Dovitinib ++++

FLT3, IC50: 1 nM

c-Kit {[allProObj[0].p_purity_real_show]}
Denfivontinib ++++

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FLT3, IC50: 0.4 nM

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TAK-659 HCl ++

FLT3, IC50: 4.6 nM

Syk {[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

5'-Fluoroindirubinoxime 生物活性

描述 5'-Fluoroindirubinoxime (5’-FIO, compound 13), an Indirubin (HY-N0117) derivative, is a potent FLT3 inhibitor, with an IC50 of 15 nM. 5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC50 values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively[1]. Indirubin derivatives showed potent antiproliferative activity on various human cancer cells and oncogenic RK3E-ras rat kidney cells, with IC(50) ranging from 1 to 12 mumol/L. Treatment with indirubin derivatives induced the activation of caspase-7 followed by apoptosis in RK3E-ras cells. Indirubin derivatives showed strong antitumor activity in rat solid and oral tumor models. Direct injection of indirubin derivatives every other day for 10 days induced significant inhibition of tumor growth in Sprague-Dawley rats bearing RK3E-ras-induced tumors. Histologically, treatment with indirubin derivatives caused significant inhibition of tumor formation with increased apoptosis and decreased tumor cell proliferation. Novel indirubin derivatives 5'-nitro-indirubinoxime, 5'-fluoro-indirubinoxime, and 5'-trimethylacetamino-indirubinoxime effectively arrested the tumor growth by inhibiting cell proliferation and inducing apoptosis[2].

5'-Fluoroindirubinoxime 参考文献

[1]Choi SJ, Moon MJ, Lee SD, Choi SU, Han SY, Kim YC. Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg Med Chem Lett. 2010 Mar 15;20(6):2033-7

[2]Kim SA, Kim YC, Kim SW, Lee SH, Min JJ, Ahn SG, Yoon JH. Antitumor activity of novel indirubin derivatives in rat tumor model. Clin Cancer Res. 2007 Jan 1;13(1):253-9

5'-Fluoroindirubinoxime 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.39mL

0.68mL

0.34mL

16.93mL

3.39mL

1.69mL

33.87mL

6.77mL

3.39mL

5'-Fluoroindirubinoxime 技术信息

CAS号861214-33-7
分子式C16H10FN3O2
分子量 295.268
别名 5'-FIO;PD 082106;5′-Fluoroindirubinoxime;5’-FIO;compound 13
运输蓝冰
存储条件

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 85 mg/mL(287.87 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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