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描述 | 4E2RCat obstructs the binding between eIF4E, the cap-binding element, and eIF4G, the extensive scaffolding molecule, thereby halting cap-dependent translation. This compound notably curtails the replication of HCoV-229E, leading to a reduction in both the proportion of cells infected and the titers of infectious virus inside and outside the cells. The inhibition of cap-dependent translation by 4E2RCat is contingent on the dosage. While it impedes cap-dependent FF translation, it does not affect EMCV IRES-mediated Ren translation. The suppression of coronavirus replication by 4E2RCat is influenced by both the concentration and duration of exposure[1]. |
Animal study | 4E2RCat suppresses protein synthesis within living organisms, and this effect is not due to an escalation in cell mortality[1]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.19mL 0.44mL 0.22mL |
10.97mL 2.19mL 1.10mL |
21.93mL 4.39mL 2.19mL |
CAS号 | 432499-63-3 |
分子式 | C22H14ClNO4S2 |
分子量 | 455.934 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 20 mg/mL(43.87 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |