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4E2RCat

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Chemical Structure| 432499-63-3 同义名 : -
CAS号 : 432499-63-3
货号 : A887504
分子式 : C22H14ClNO4S2
纯度 : 99%+
分子量 : 455.934
MDL号 : MFCD03706106
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 20 mg/mL(43.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 4E2RCat obstructs the binding between eIF4E, the cap-binding element, and eIF4G, the extensive scaffolding molecule, thereby halting cap-dependent translation. This compound notably curtails the replication of HCoV-229E, leading to a reduction in both the proportion of cells infected and the titers of infectious virus inside and outside the cells. The inhibition of cap-dependent translation by 4E2RCat is contingent on the dosage. While it impedes cap-dependent FF translation, it does not affect EMCV IRES-mediated Ren translation. The suppression of coronavirus replication by 4E2RCat is influenced by both the concentration and duration of exposure[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.19mL

0.44mL

0.22mL

10.97mL

2.19mL

1.10mL

21.93mL

4.39mL

2.19mL
参考文献

[1]Cencic R, et al. Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication. J Virol. 2011 Jul;85(13):6381-9.