There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
4-Hydroxyretinoic acid (4-HRA) is a naturally occurring derivative of retinoids, exhibiting a wide range of biological effects. It is synthesized from retinol through the catalysis of cytochrome P-450 isozyme(s) and primarily metabolized by the liver. Additionally, 4-Hydroxyretinoic acid serves as a substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7. It modulates gene expression and cell differentiation by binding to the nuclear receptor RAR (Retinoic Acid Receptor) and activating RARs and RXR-alpha, leading to apoptosis in cancer cells. Moreover, 4-Hydroxyretinoic acid plays roles in immune regulation, neuroprotection, and antioxidation processes[1][2].
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