产品说明书

4-Hydroxyretinoic acid

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Chemical Structure| 66592-72-1 同义名 : all-trans-4-hydroxy Retinoic Acid;4-hydroxy RA;4-OH-atRA
CAS号 : 66592-72-1
货号 : A1209873
分子式 : C20H28O3
纯度 : 98%+
分子量 : 316.435
MDL号 : MFCD00872034
存储条件：

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(331.82 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 4-Hydroxyretinoic acid (4-HRA) is a naturally occurring derivative of retinoids, exhibiting a wide range of biological effects. It is synthesized from retinol through the catalysis of cytochrome P-450 isozyme(s) and primarily metabolized by the liver. Additionally, 4-Hydroxyretinoic acid serves as a substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7. It modulates gene expression and cell differentiation by binding to the nuclear receptor RAR (Retinoic Acid Receptor) and activating RARs and RXR-alpha, leading to apoptosis in cancer cells. Moreover, 4-Hydroxyretinoic acid plays roles in immune regulation, neuroprotection, and antioxidation processes[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.16mL

0.63mL

0.32mL

15.80mL

3.16mL

1.58mL

31.60mL

6.32mL

3.16mL
参考文献

[1]Samokyszyn VM, et al. 4-hydroxyretinoic acid, a novel substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7. J Biol Chem. 2000 Mar 10;275(10):6908-14.

[2]Duell EA, et al. Human skin levels of retinoic acid and cytochrome P-450-derived 4-hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor-mediated transcription in vitro. J Clin Invest. 1992 Oct;90(4):1269-74.