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/ 4-Hydroxybenzyl alcohol

对羟基苯甲醇 /4-Hydroxybenzyl alcohol {[allProObj[0].p_purity_real_show]}

货号：A337115 同义名： NSC 227926;P-Methylolphenol

4-Hydroxybenzyl alcohol, a natural product isolated and purified from the herbs of Cistanche deserticola Ma, exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway.

4-Hydroxybenzyl alcohol 化学结构 CAS号：623-05-2
4-Hydroxybenzyl alcohol 化学结构
CAS号：623-05-2
4-Hydroxybenzyl alcohol 3D分子结构
CAS号：623-05-2
4-Hydroxybenzyl alcohol 化学结构 CAS号：623-05-2
4-Hydroxybenzyl alcohol 3D分子结构 CAS号：623-05-2
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4-Hydroxybenzyl alcohol 纯度/质量文件 产品仅供科研

货号：A337115 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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4-Hydroxybenzyl alcohol 生物活性

描述 4-Hydroxybenzyl Alcohol (4-HBA), a kind of phenolic compounds, has been found in many plants, like Gastrodia elata Blume. It has many biological activities, such as anti-angiogenic, anti-inflammatory and anti-nociceptive activity [1] . In vitro studies, it was found that 4-HBA could significantly increase the astrocytes' ability of anti-oxidation by activation of Nrf2 and induction of HO-1. For example, after 6 hrs treatment with 100 μM 4-HBA, the survival rate of C6 cells in hydrogen peroxide (100 μM, 1 hr) would be increased from 54.2±0.7% to 85.9±1.5% [2] . In vivo studies, 4-HBA could be used in some neurological disorders. When given 50 and 100 mg/kg, the rats with cerebral injury would have better performance in many neurological indicators, such as smaller cerebral infarct size, little degenerated neurons and so on [3] .

4-Hydroxybenzyl alcohol 参考文献

[1]Lim EJ, Kang HJ, et al. Anti-angiogenic, anti-inflammatory and anti-nociceptive activity of 4-hydroxybenzyl alcohol. J Pharm Pharmacol. 2007;59(9):1235-40.

[2]Luo L, Kim SW, et al. Anti-oxidative effects of 4-hydroxybenzyl alcohol in astrocytes confer protective effects in autocrine and paracrine manners. PLoS One. 2017;12(5):e0177322.

[3]Yu SS, Zhao J, et al. 4-hydroxybenzyl alcohol ameliorates cerebral injury in rats by antioxidant action. Neurochem Res. 2011;36(2):339-46.

4-Hydroxybenzyl alcohol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

8.06mL

1.61mL

0.81mL

40.28mL

8.06mL

4.03mL

80.55mL

16.11mL

8.06mL

4-Hydroxybenzyl alcohol 技术信息

CAS号623-05-2
分子式C7H8O2
分子量 124.14
别名 NSC 227926;P-Methylolphenol;p-Hydroxybenzyl Alcohol;4-Methylolphenol
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Room Temperature
溶解度

DMSO: 50 mg/mL(402.77 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: 4-Hydroxybenzyl alcohol | NSC 227926;P-Methylolphenol;p-Hydroxybenzyl Alcohol;4-Methylolphenol | AmBeed-信号通路专用抑制剂 | 4-Hydroxybenzyl alcohol 纯度/质量文件 | 4-Hydroxybenzyl alcohol 生物活性 | 4-Hydroxybenzyl alcohol 参考文献 | 4-Hydroxybenzyl alcohol 实验方案 | 4-Hydroxybenzyl alcohol 技术信息

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