4-Hydroxybenzyl alcohol, a natural product isolated and purified from the herbs of Cistanche deserticola Ma, exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway.
4-Hydroxybenzyl Alcohol (4-HBA), a kind of phenolic compounds, has been found in many plants, like Gastrodia elata Blume. It has many biological activities, such as anti-angiogenic, anti-inflammatory and anti-nociceptive activity [1] . In vitro studies, it was found that 4-HBA could significantly increase the astrocytes' ability of anti-oxidation by activation of Nrf2 and induction of HO-1. For example, after 6 hrs treatment with 100 μM 4-HBA, the survival rate of C6 cells in hydrogen peroxide (100 μM, 1 hr) would be increased from 54.2±0.7% to 85.9±1.5% [2] . In vivo studies, 4-HBA could be used in some neurological disorders. When given 50 and 100 mg/kg, the rats with cerebral injury would have better performance in many neurological indicators, such as smaller cerebral infarct size, little degenerated neurons and so on [3] .
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