货号:A115979
同义名:
3,4-二羟基苯基乙酸
/ 3,4-Dihydroxyphenylacetic Acid;NSC 73191
Dopac是多巴胺的代谢产物,能够调节醛脱氢酶(ALDH)活性,并保护细胞免受乙醛诱导的细胞毒性。
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描述 | 3, 4-Dihydroxyphenylacetic acid (DOPAC) is a phenolic acid with strong anti-oxidative activity. DOPAC and 3-hydroxyphenylacetic acid (3-HPAA) are intestinal metabolites of the dietary flavonoid quercetin. DOPAC reportedly showed anxiolytic activity after i.p. administration in rats[2]. DOPAC is one of the major colonic microflora-produced catabolites of quercetin glycosides, such as quercetin 4'-glucoside derived from onion. DOPAC was shown to enhance not only the total ALDH activity, but also the gene expression of ALDH1A1, ALDH2 and ALDH3A1 in a concentration-dependent manner. DOPAC simultaneously stimulated the nuclear translocation of NFE2-related factor 2 and aryl hydrocarbon receptor. The pretreatment of DOPAC completely protected the cells from the acetaldehyde-induced cytotoxicity[3]. Protocatechuic acid and DOPAC inhibited the formation of Amadori compounds, fluorescent AGEs (IC50 = 62.1 ± 1.4 and 155.4 ± 1.1 μM, respectively), and Nε-(carboxymethyl)lysine (IC50 = 535.3 ± 1.1 and 751.2 ± 1.0 μM, respectively)[4]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
5.95mL 1.19mL 0.59mL |
29.74mL 5.95mL 2.97mL |
59.47mL 11.89mL 5.95mL |
CAS号 | 102-32-9 |
分子式 | C8H8O4 |
分子量 | 168.15 |
别名 | 3,4-二羟基苯基乙酸 ;3,4-Dihydroxyphenylacetic Acid;NSC 73191;DOPAC |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Inert atmosphere,Room Temperature |
溶解方案 |
DMSO: 105 mg/mL(624.44 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 50 mg/mL(297.35 mM),配合低频超声助溶 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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动物实验配方 |