产品说明书
3,4-Dihydroxybenzeneacetic acid
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同义名 : | 3,4-二羟基苯基乙酸 ;3,4-Dihydroxyphenylacetic Acid;NSC 73191;DOPAC |
| CAS号 : | 102-32-9 | |
| 货号 : | A115979 | |
| 分子式 : | C8H8O4 | |
| 纯度 : | 98% | |
| 分子量 : | 168.15 | |
| MDL号 : | MFCD00004338 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(624.44 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(297.35 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 3, 4-Dihydroxyphenylacetic acid (DOPAC) is a phenolic acid with strong anti-oxidative activity. DOPAC and 3-hydroxyphenylacetic acid (3-HPAA) are intestinal metabolites of the dietary flavonoid quercetin. DOPAC reportedly showed anxiolytic activity after i.p. administration in rats[2]. DOPAC is one of the major colonic microflora-produced catabolites of quercetin glycosides, such as quercetin 4'-glucoside derived from onion. DOPAC was shown to enhance not only the total ALDH activity, but also the gene expression of ALDH1A1, ALDH2 and ALDH3A1 in a concentration-dependent manner. DOPAC simultaneously stimulated the nuclear translocation of NFE2-related factor 2 and aryl hydrocarbon receptor. The pretreatment of DOPAC completely protected the cells from the acetaldehyde-induced cytotoxicity[3]. Protocatechuic acid and DOPAC inhibited the formation of Amadori compounds, fluorescent AGEs (IC50 = 62.1 ± 1.4 and 155.4 ± 1.1 μM, respectively), and Nε-(carboxymethyl)lysine (IC50 = 535.3 ± 1.1 and 751.2 ± 1.0 μM, respectively)[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.95mL 1.19mL 0.59mL |
29.74mL 5.95mL 2.97mL |
59.47mL 11.89mL 5.95mL |
| 参考文献 |
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