There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
PTP Inhibitor I is a photoreversible covalent Inhibitor of PTP (Protein Tyrosine Phosphatases) with Ki value of 42μM for PTP1B. PTP Inhibitor I could bind to the PTP active site as a phosphotyrosine mimetic. Its phenyl ring could engage in hydrophobic interactions with the protein as the phenyl ring of a substrate does, and the electron-rich halogen atom could mimic the negatively charged phosphate oxyanions. Binding of PTP Inhibitor I to the PTP active site in such a manner would place the R-carbon, which is highly susceptible to nucleophilic attack, next to the catalytic cysteine. An SN2 reaction between 1 and the cysteine thiol would result in the formation of a covalent enzyme-inhibitor adduct through a stable thioether linkage and loss of phosphatase activity. Treatment with PTP Inhibitor I>300μM resulted in the hyperphosphorylation of a protein at 110 kDa in human B cells post 3min, consistent with inhibition of a PTP(s) which normally dephosphorylates this protein. Also it decreased the phosphorylation level of a 50 kDa protein at concentrations as low as 30μM.
作用机制
PTP Inhibitor I could bind to the PTP active site as a phosphotyrosine mimetic.[1]
搜索
HazMat Fee +
