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2-溴-4'-羟基乙酰苯 /2-Bromo-4'-hydroxyacetophenone {[allProObj[0].p_purity_real_show]}

货号:A172579 同义名: 2-溴-4'-羟基苯乙酮 / PTP Inhibitor I;4-Hydroxyphenacyl bromide Ambeed 开学季,买赠积分,赢豪礼

PTP Inhibitor I is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor, it binds to PTPs with Ki values of 43 and 42 μM and Kinact values of 0.40 and 0.57/min for SHP-1(△SH2) and PTP1B, respectively.

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
2-Bromo-4'-hydroxyacetophenone 化学结构 CAS号:2491-38-5
2-Bromo-4'-hydroxyacetophenone 化学结构
CAS号:2491-38-5
2-Bromo-4'-hydroxyacetophenone 3D分子结构
CAS号:2491-38-5
2-Bromo-4'-hydroxyacetophenone 化学结构 CAS号:2491-38-5
2-Bromo-4'-hydroxyacetophenone 3D分子结构 CAS号:2491-38-5
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2-Bromo-4'-hydroxyacetophenone 纯度/质量文件 产品仅供科研

货号:A172579 标准纯度: {[allProObj[0].p_purity_real_show]}
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2-Bromo-4'-hydroxyacetophenone 生物活性

描述 PTP Inhibitor I is a photoreversible covalent Inhibitor of PTP (Protein Tyrosine Phosphatases) with Ki value of 42μM for PTP1B. PTP Inhibitor I could bind to the PTP active site as a phosphotyrosine mimetic. Its phenyl ring could engage in hydrophobic interactions with the protein as the phenyl ring of a substrate does, and the electron-rich halogen atom could mimic the negatively charged phosphate oxyanions. Binding of PTP Inhibitor I to the PTP active site in such a manner would place the R-carbon, which is highly susceptible to nucleophilic attack, next to the catalytic cysteine. An SN2 reaction between 1 and the cysteine thiol would result in the formation of a covalent enzyme-inhibitor adduct through a stable thioether linkage and loss of phosphatase activity. Treatment with PTP Inhibitor I>300μM resulted in the hyperphosphorylation of a protein at 110 kDa in human B cells post 3min, consistent with inhibition of a PTP(s) which normally dephosphorylates this protein. Also it decreased the phosphorylation level of a 50 kDa protein at concentrations as low as 30μM.
作用机制 PTP Inhibitor I could bind to the PTP active site as a phosphotyrosine mimetic.[1]

2-Bromo-4'-hydroxyacetophenone 参考文献

[1]α-Haloacetophenone Derivatives As Photoreversible Covalent Inhibitors of Protein Tyrosine Phosphatases

2-Bromo-4'-hydroxyacetophenone 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.65mL

0.93mL

0.47mL

23.25mL

4.65mL

2.33mL

46.50mL

9.30mL

4.65mL

2-Bromo-4'-hydroxyacetophenone 技术信息

CAS号2491-38-5
分子式C8H7BrO2
分子量 215.044
别名 2-溴-4'-羟基苯乙酮 ;PTP Inhibitor I;4-Hydroxyphenacyl bromide;Protein Tyrosine Phosphatase Inhibitor I;SHP-1 Inhibitor II;α-Bromo-4-hydroxyacetophenone
运输蓝冰
存储条件

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 250 mg/mL(1162.55 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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