(S,R,S)-AHPC
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货号：A285256
MDK7526 is a ligand of Von Hippel–Lindau protein, that can be used for making proteolysis targeting chimeras (PROTACs).
(S,R,S)-AHPC 化学结构
(S,R,S)-AHPC 3D分子结构
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(S,R,S)-AHPC 纯度/质量文件 产品仅供科研
货号：A285256
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(S,R,S)-AHPC 质控信息
(S,R,S)-AHPC 生物活性
描述
Protein homeostasis networks are highly regulated systems responsible for maintaining the health and productivity of cells. Small-molecule-based proteolysis targeting chimeras (PROTACs) have been developed to degrade targeted proteins. The von Hippel–Lindau (VHL) is a component of a multi-subunit E3 ubiquitin ligase that functions with a cullin RING ligase under normoxic conditions to degrade HIF1a[3]
作用机制
MDK7526 contains an isoxazolylacetamide fragment, which was designed to interact with a water molecule previously identified as an important part of the hydrogen-bonding network between VHL and HIF1a.
(S,R,S)-AHPC 参考文献
[1] Bondeson DP, Crews CM. Targeted Protein Degradation by Small Molecules. Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:107-123.
[2] Bondeson DP, Mares A, et al. Catalytic in vivo protein knockdown by small-molecule PROTACs. Nat Chem Biol. 2015 Aug;11(8):611-7.
[3] Buckley DL, Gustafson JL, Van Molle I, Roth AG, Tae HS, Gareiss PC, Jorgensen WL, Ciulli A, Crews CM. Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α. Angew Chem Int Ed Engl. 2012 Nov 12;51(46):11463-7. doi: 10.1002/anie.201206231. Epub 2012 Oct 12. PMID: 23065727; PMCID: PMC3519281.
(S,R,S)-AHPC 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.32mL
0.46mL
0.23mL
11.61mL
2.32mL
1.16mL
23.23mL
4.65mL
2.32mL
(S,R,S)-AHPC 技术信息
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