产品说明书
(S,R,S)-AHPC
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同义名 : | - |
| CAS号 : | 1448297-52-6 | |
| 货号 : | A285256 | |
| 分子式 : | C22H30N4O3S | |
| 纯度 : | 97% | |
| 分子量 : | 430.564 | |
| MDL号 : | MFCD29049827 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(243.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 25 mg/mL(58.06 mM) |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Protein homeostasis networks are highly regulated systems responsible for maintaining the health and productivity of cells. Small-molecule-based proteolysis targeting chimeras (PROTACs) have been developed to degrade targeted proteins. The von Hippel–Lindau (VHL) is a component of a multi-subunit E3 ubiquitin ligase that functions with a cullin RING ligase under normoxic conditions to degrade HIF1a[3]. MDK7526 is a ligand of Von Hippel–Lindau protein that can be used for making PROTACs. | ||
| 作用机制 | MDK7526 contains an isoxazolylacetamide fragment, which was designed to interact with a water molecule previously identified as an important part of the hydrogen-bonding network between VHL and HIF1a. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.32mL 0.46mL 0.23mL |
11.61mL 2.32mL 1.16mL |
23.23mL 4.65mL 2.32mL |
| 参考文献 |
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