货号:A1163389
同义名:
α-Melanocyte-Stimulating Hormone TFA; α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
α-MSH is endogenous agonist of melanocortin receptor with Ki values of 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively.
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描述 | α-MSH (swine) trifluoroacetate (α-melanocyte stimulating hormone) is a pleiotropic neuropeptide and its renoprotective effects have been demonstrated in models of acute kidney injury. α-MSH treatment reduced urine flow and impaired recovery of glomerular filtration rate (GFR) compared to controls. After each dose of α-MSH, a trend towards reduced mean arterial blood pressure and increased heart rate was observed. α-MSH did not affect expression of inflammatory markers. α-MSH impaired recovery of renal function in the first ten hours following DBD (deceased brain dead) kidney transplantation possibly due to hemodynamic changes[1]. alpha-melanocyte stimulating hormone analogue AP214 can protect against acute kidney injury in higher vertebrates[2]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
0.56mL 0.11mL 0.06mL |
2.81mL 0.56mL 0.28mL |
5.62mL 1.12mL 0.56mL |
CAS号 | 171869-93-5 |
分子式 | C79H110F3N21O21S |
分子量 | 1778.91 |
SMILES Code | OC1=CC=C(C=C1)C[C@H](NC([C@H](CO)NC(C)=O)=O)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@@H](CCCCN)C(N4[C@@H](CCC4)C(N[C@H](C(N)=O)C(C)C)=O)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F |
MDL No. | MFCD00133062 |
别名 | α-Melanocyte-Stimulating Hormone TFA; α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt); Ac-SYSMEHFRWGKPV-NH2; α-Melanocyte-stimulating Hormone; alpha-MSH TFA |
运输 | 蓝冰 |
InChI Key | FEOXCJFWEWYJIH-VLZMNQITSA-N |
Pubchem ID | 145710782 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C |
溶解方案 |
H2O: 25 mg/mL(14.05 mM),配合低频超声助溶 |