α-MSH TFA

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Chemical Structure| 171869-93-5 同义名 : α-Melanocyte-Stimulating Hormone TFA; α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt); Ac-SYSMEHFRWGKPV-NH2; α-Melanocyte-stimulating Hormone; alpha-MSH TFA
CAS号 : 171869-93-5
货号 : A1163389
分子式 : C79H110F3N21O21S
纯度 : 99%
分子量 : 1778.91
MDL号 : MFCD00133062
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 25 mg/mL(14.05 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 α-MSH (swine) trifluoroacetate (α-melanocyte stimulating hormone) is a pleiotropic neuropeptide and its renoprotective effects have been demonstrated in models of acute kidney injury. α-MSH treatment reduced urine flow and impaired recovery of glomerular filtration rate (GFR) compared to controls. After each dose of α-MSH, a trend towards reduced mean arterial blood pressure and increased heart rate was observed. α-MSH did not affect expression of inflammatory markers. α-MSH impaired recovery of renal function in the first ten hours following DBD (deceased brain dead) kidney transplantation possibly due to hemodynamic changes[1]. alpha-melanocyte stimulating hormone analogue AP214 can protect against acute kidney injury in higher vertebrates[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.56mL

0.11mL

0.06mL

2.81mL

0.56mL

0.28mL

5.62mL

1.12mL

0.56mL
参考文献

[1]van Rijt WG, Secher N, Keller AK, et al. α-Melanocyte stimulating hormone treatment in pigs does not improve early graft function in kidney transplants from brain dead donors. PLoS One. 2014;9(4):e94609. Published 2014 Apr 11

[2]Simmons MN, Subramanian V, Crouzet S, et al. Alpha-melanocyte stimulating hormone analogue AP214 protects against ischemia induced acute kidney injury in a porcine surgical model [published correction appears in J Urol. 2010 Jul;184(1):398. Neilsen, Søren [corrected to Nielsen, Søren]]. J Urol. 2010;183(4):1625‐1629