Buparlisib (BKM120; NVP-BKM120) 是一种泛 I 类 PI3K 抑制剂，对 p110α 的 IC50 为 52 nM，对 p110β 为 166 nM，对 p110δ 为 116 nM，对 p110γ 为 262 nM。

3-Methyladenine is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM.

Taselisib (GDC-0032) 是一种针对PIK3CA突变的有效PI3K抑制剂，对PI3Kδ、PI3Kα、PI3Kγ和PI3Kβ的Ki值分别为0.12 nM、0.29 nM、0.97 nM和9.1 nM。

Autophinib is an ATP-competitive inhibitor of the VPS34 with IC50 of 19 nM, also inhibitor of starvation- and Rapamycin-induced autophagy with IC50 of 40 and 90 nM respectively.

SAR405是一种首创的选择性ATP竞争性PI3K III类（PIK3C3）同工酶Vps34抑制剂，IC50为1.2 nM，Kd为1.5 nM。它抑制由饥饿或mTOR抑制引起的自噬，并表现出抗癌活性。

PIK-III, which is a selective inhibitor of ​VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates.

Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro,which does not significantly inhibit the isoforms of class I as well as class II PI3Ks.

Vps34-IN1 is a potent inhibitor of the class III phosphoinositide 3-kinase (PI3K) vacuolar protein sorting 34 (Vsp34) with IC50 of 15 nM.