Doramapimod is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ.

SB-202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase with IC50 values of 50 nM and 100 nM for p38α and p38β respectively; also shows slightly weaker activity for BRD4 (Kd=3.4 μM).

LY2228820 is a potent p38MAPK inhibitor with IC50 of 7 nM and 3 nM for p38αMAPK and p38βMAPK.

VX-702 是一种选择性 p38α MAPK 抑制剂，其选择性是 p38β MAPK 的 14 倍。

PH-797804 is a pyridinone inhibitor of p38α with IC50 of 26 nM, being 4-fold selective versus p38β and does not inhibit JNK2.

Neflamapimod（VX-745）是一种有效的、能穿透血脑屏障的高选择性p38α抑制剂，对p38α的IC50值为10 nM，对p38β的IC50值为220 nM。Neflamapimod（VX-745）具有抗炎活性。

TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, being 28-fold selective for p38α over p38β, showing no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.

SB 239063是一种强效、选择性、口服活性p38 MAPK抑制剂，对重组人p38α的IC50为44 nM。它对p38α和p38β具有相似的抑制活性，对p38γ或p38δ无影响。它用于抗哮喘治疗和阿尔茨海默病等条件下的记忆增强。

Losmapimod(GSK-AHAB) 是一种选择性、高效且口服活性的 p38 MAPK 抑制剂，对 p38α 的 pKi 为 8.1，对 p38β 的 pKi 为 7.6。

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.

Pamapimod is a selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 mM, respectively with no activity against p38delta or p38gamma isoforms.