甲磺氮草脲 /Tolazamide
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货号：A899724
同义名：
托拉唑胺
/ U-17835;NSC 70762
Tolazamide is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity.
Tolazamide 化学结构
Tolazamide 3D分子结构
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Tolazamide 纯度/质量文件 产品仅供科研
货号：A899724
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Tolazamide 质控信息
Tolazamide 生物活性
描述
Tolazamide is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. Tolazamide had two general classes of binding sites (i.e., high and low affinity) for normal and glycated HSA. The higher affinity sites had binding constants of around 4.3-6.0 × 104 M-1 for these interactions at pH 7.4 and 37 °C, while the lower affinity sites had binding strengths of 4.9-9.1 × 103 M-1[3] [4] [5]
Tolazamide 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT02456428
-
Completed
-
Canada, Quebec
... 展开 >> Lady Davis Institute for Medical Research, Jewish General Hospital
Montreal, Quebec, Canada, H3T1E2 收起 <<
NCT02476760
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Completed
-
Canada, Quebec
... 展开 >> Lady Davis Institute for Medical Research, Jewish General Hospital
Montreal, Quebec, Canada, H3T1E2 收起 <<
NCT02475499
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Completed
-
Canada, Quebec
... 展开 >> Lady Davis Institute for Medical Research, Jewish General Hospital
Montreal, Quebec, Canada, H3T1E2 收起 <<
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Tolazamide 参考文献
[1] Schmitt JK, Johns SB. Altering therapy of type II diabetes mellitus from insulin to tolazamide increases blood pressure in spite of weight loss. Am J Hypertens. 1995 May;8(5 Pt 1):520-3.
[2] Sanders R, Faro B, et al. Adjunctive use of tolazamide in newly-diagnosed diabetic children. Horm Metab Res. 1990 Nov;22(11):576-80.
[3] Tao P, Li Z, Woolfork AG, Hage DS. Characterization of tolazamide binding with glycated and normal human serum albumin by using high-performance affinity chromatography. J Pharm Biomed Anal. 2019 Mar 20;166:273-280
[4] Maloff BL, Lockwood DH. In vitro effects of a sulfonylurea on insulin action in adipocytes. Potentiation of insulin-stimulated hexose transport. J Clin Invest. 1981 Jul;68(1):85-90
[5] Cortes P, Riser BL, Asano K, Rodríguez-Barbero A, Narins RG, Yee J. Effects of oral antihyperglycemic agents on extracellular matrix synthesis by mesangial cells. Kidney Int. 1998 Dec;54(6):1985-98
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Tolazamide 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.21mL
0.64mL
0.32mL
16.06mL
3.21mL
1.61mL
32.11mL
6.42mL
3.21mL
Tolazamide 技术信息
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