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首页 / 抑制剂/激动剂 / 细胞骨架 / Gap Junction / Tonabersat

Tonabersat {[allProObj[0].p_purity_real_show]}

货号：A468702 同义名： SB-220453

Tonabersat is a gap-junction modulator.

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Tonabersat 化学结构 CAS号：175013-84-0
Tonabersat 化学结构
CAS号：175013-84-0
Tonabersat 3D分子结构
CAS号：175013-84-0
Tonabersat 化学结构 CAS号：175013-84-0
Tonabersat 3D分子结构 CAS号：175013-84-0
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Tonabersat 纯度/质量文件 产品仅供科研

货号：A468702 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Tonabersat 生物活性

描述 Tonabersat is a gap-junction modulator.

Tonabersat 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00332007 Migraine With Aura Phase 2 Completed - Denmark ... 展开 >> Danish Headache Centre, Department of Neurology, Glostrup Hospital Copenhagen, Denmark 收起 <<
NCT00534560 Migraine Without Aura ... 展开 >> Migraine With Aura 收起 << Phase 2 Completed - -
NCT00311662 Migraine Without Aura ... 展开 >> Migraine With Aura 收起 << Phase 2 Completed - Denmark ... 展开 >> Glostrup Amtssygehus, Neurologisk Ambulatorium N01 Copenhagen, Denmark, Glostrup 2600 Bispebjerg Hospital, Neurolgisk Afdeling N Copenhagen, Denmark, Kobenhavn NV 2400 Hungary Kenézy Gyula County Hospital, Dept of Neurology Debrecen, Hungary, Debrecen 1145 Petz Aladár Megyei Oktató Kórház Gyor, Hungary, Gyor 9024 Borsod Abauj Zemplén Megyei Kórház, Neurologiai Osztaly Miskolc, Hungary, Miskolc 3526 Zala County Hospital, Department of Cardiology Zalaegerszeg, Hungary, Zalaegerszeg 8900 South Africa Quinta-Med Bloemfontein, South Africa, Bloemfontein 9301 Chris Barnard Memorial Hospital Cape Town, South Africa, West Cape 8001 St. Augustine's Medical Mews Durban, South Africa, KZ-Natal 4001 Francois Le Clus Johannesburg, South Africa, Gauteng 1619 Dr I Engelbrecht Lyttleton, South Africa, Guateng 0157 Pretoria East Hospital, Neuro-Orthopaedic Unit Pretoria, South Africa, Gauteng 0044 Intercare Corporate Office Pretoria, South Africa, Gauteng 0081 Dr J Bouwer Pretoria, South Africa, Gauteng 0082 Little Company of Mary, Neurospinal Building Pretoria, South Africa, Gauteng 0181 SCION Clinical Research, 316 Medi-Clinic Heart Hospital Pretoria, South Africa, Guateng 0002 United Kingdom The National Hospital for Neurology & Neurosurgery London, United Kingdom, WC1N 3BG 收起 <<

Tonabersat 参考文献

[1]Chen Q, Boire A, et al. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature. 2016 May 26;533(7604):493-498.

[2]Silberstein SD, Schoenen J, et al. Tonabersat, a gap-junction modulator: efficacy and safety in two randomized, placebo-controlled, dose-ranging studies of acute migraine. Cephalalgia. 2009 Nov;29 Suppl 2:17-27.

Tonabersat 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.26mL

12.76mL

2.55mL

1.28mL

25.52mL

5.10mL

2.55mL

Tonabersat 技术信息

CAS号175013-84-0
分子式C20H19ClFNO4
分子量 391.821
别名 SB-220453
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末

溶解度

DMSO: 105 mg/mL(267.98 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Tonabersat | 175013-84-0 | SB-220453 | SB220453 | SB 220453 | Gap Junction Modulator | Cytoskeleton | Gap Junction Protein | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Tonabersat 纯度/质量文件 | Tonabersat 生物活性 | Tonabersat 临床数据 | Tonabersat 参考文献 | Tonabersat 实验方案 | Tonabersat 技术信息

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