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1-(2,3-二(噻吩-2-基)喹啉-6-基)-3-(2-甲氧基乙基)脲 /Ac-CoA Synthase Inhibitor1 {[allProObj[0].p_purity_real_show]}

货号:A314446 同义名: Acetyl-CoA Synthase Inhibitor;ACSS2 inhibitor Ambeed 开学季,买赠积分,赢豪礼

Ac-CoA Synthase Inhibitor is a reversible inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2) with IC50 of ~ 600 nM.

Ac-CoA Synthase Inhibitor1 化学结构 CAS号:508186-14-9
Ac-CoA Synthase Inhibitor1 化学结构
CAS号:508186-14-9
Ac-CoA Synthase Inhibitor1 3D分子结构
CAS号:508186-14-9
Ac-CoA Synthase Inhibitor1 化学结构 CAS号:508186-14-9
Ac-CoA Synthase Inhibitor1 3D分子结构 CAS号:508186-14-9
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Ac-CoA Synthase Inhibitor1 纯度/质量文件 产品仅供科研

货号:A314446 标准纯度: {[allProObj[0].p_purity_real_show]}
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Ac-CoA Synthase Inhibitor1 生物活性

描述 Acetyl-CoA represents a central node of carbon metabolism that plays a key role in bioenergetics, cell proliferation and the regulation of gene expression. The nucleocytosolic acetyl-CoA synthetase enzyme, ACSS2, supplies a key source of acetyl-CoA for tumors by capturing acetate as a carbon source[1]. ACSS2 inhibitor (quinoxaline) is a reversible inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2) with IC50 of ~ 600 nM. This quinoxaline compound inhibits the ability of HepG2 cells to incorporate [14C]acetate into lipids with IC50 of 6.8 μM, and also inhibits HepG2 utilization of [14C]acetate for histone acetylation with IC50 of 5.5 μM[1].

Ac-CoA Synthase Inhibitor1 参考文献

[1]Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz AK, Walters H, Tantawy MN, Fu A, Manning HC, Horton JD, Hammer RE, McKnight SL, Tu BP. Acetate dependence of tumors. Cell. 2014 Dec 18;159(7):1591-602. doi: 10.1016/j.cell.2014.11.020. PMID: 25525877; PMCID: PMC4272450.

Ac-CoA Synthase Inhibitor1 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.44mL

0.49mL

0.24mL

12.18mL

2.44mL

1.22mL

24.36mL

4.87mL

2.44mL

Ac-CoA Synthase Inhibitor1 技术信息

CAS号508186-14-9
分子式C20H18N4O2S2
分子量 410.512
别名 Acetyl-CoA Synthase Inhibitor;ACSS2 inhibitor;Ac-CoA Synthase Inhibitor I;ACSS-1;VY-3-249;MDK6149;ACCS2 Inhibitor
运输蓝冰
存储条件

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 30 mg/mL(73.08 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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