1-(2,3-二(噻吩-2-基)喹啉-6-基)-3-(2-甲氧基乙基)脲 /Ac-CoA Synthase Inhibitor1
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货号：A314446
同义名：
Acetyl-CoA Synthase Inhibitor;ACSS2 inhibitor
Ac-CoA Synthase Inhibitor is a reversible inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2) with IC50 of ~ 600 nM.
Ac-CoA Synthase Inhibitor1 化学结构
Ac-CoA Synthase Inhibitor1 3D分子结构
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Ac-CoA Synthase Inhibitor1 纯度/质量文件 产品仅供科研
货号：A314446
标准纯度：
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Ac-CoA Synthase Inhibitor1 质控信息
Ac-CoA Synthase Inhibitor1 生物活性
描述
Acetyl-CoA represents a central node of carbon metabolism that plays a key role in bioenergetics, cell proliferation and the regulation of gene expression. The nucleocytosolic acetyl-CoA synthetase enzyme, ACSS2, supplies a key source of acetyl-CoA for tumors by capturing acetate as a carbon source[1] 50 of ~ 600 nM. This quinoxaline compound inhibits the ability of HepG2 cells to incorporate [14C]acetate into lipids with IC50 of 6.8 μM, and also inhibits HepG2 utilization of [14C]acetate for histone acetylation with IC50 of 5.5 μM[1]
Ac-CoA Synthase Inhibitor1 参考文献
[1] Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz AK, Walters H, Tantawy MN, Fu A, Manning HC, Horton JD, Hammer RE, McKnight SL, Tu BP. Acetate dependence of tumors. Cell. 2014 Dec 18;159(7):1591-602. doi: 10.1016/j.cell.2014.11.020. PMID: 25525877; PMCID: PMC4272450.
Ac-CoA Synthase Inhibitor1 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.44mL
0.49mL
0.24mL
12.18mL
2.44mL
1.22mL
24.36mL
4.87mL
2.44mL
Ac-CoA Synthase Inhibitor1 技术信息
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