ESI-09是一种选择性EPAC1和EPAC2抑制剂，IC50分别为3.2 μM和1.4 μM。

HJC0350是一种强效且选择性的 EPAC2 抑制剂，IC50 为 0.3 μM，对 Epac1 无抑制作用。

ESI-05是一种 EPAC2 抑制剂，能够抑制 cAMP 与 EPAC2 的结合及 cAMP 介导的 EPAC2 鸟嘌呤核苷酸交换因子 (GEF) 活性，IC50 为 0.4 μM。

HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP .

EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.

8-CPT-2Me-cAMP sodium salt is a selective activator of Epac.

(R)-CE3F4 is an inhibitor of Epac with IC50 values of 4.2 and 44 μM for Epac1 and Epac2(B), respectively.

CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac), with IC50 values of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively.