ESI-09 is selective inhibitor of EPAC1 and EPAC2 with IC50 of 3.2 μM and 1.4 μM.

HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM.

ESI 05 is an inhibitor of EPAC2. It can inhibit cAMP binding to EPAC2 and cAMP mediated EPAC2 guanine nucleotide exchange factor (GEF) activity (IC50 = 0.4 μM).

HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP .

EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.

8-CPT-2Me-cAMP sodium salt is a selective activator of Epac.

(R)-CE3F4 is an inhibitor of Epac with IC50 values of 4.2 and 44 μM for Epac1 and Epac2(B), respectively.

CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac), with IC50 values of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively.