Dorzolomide HCl is a potent and water-soluble inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM respectively and used as anti-glaucoma agent.

Tioxolone, a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM, is an anti-acne preparation.

Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.