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MRT-2359
MRT-2359 is an orally effective GSPT1 degrader that can inhibit the growth of drug-resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells, with preferential activity against MYC-driven cell lines.
低至 ¥ 508 /1mg
Orforglipron
Orforglipron is an orally active GLP-1 receptor agonist that promotes insulin secretion and suppresses appetite, widely used in research on diabetes and obesity-related metabolic diseases, with detailed information available in patent WO2018056453A1.
低至 ¥ 599 /5mg
KT-474
KT-474 is a PROTAC IRAK4 degrader that demonstrates significant antitumor effects by mediating anticancer signals through IRAK4 targeted degradation.
低至 ¥ 485 /1mg
Sotorasib/索托拉西布
Sotorasib is a KRAS G12C inhibitor with an IC50 value of 5.3 nM for KRAS G12C. Sotorasib has antitumor effects and can be used in research on KRAS mutation-associated cancers.
低至 ¥ 643 /5mg
MRTX1133
MRTX1133 is a highly selective KRAS G12D inhibitor that effectively suppresses its signaling pathways.
低至 ¥ 2692 /10mg
Emavusertib
CA-4948 is a selective and orally bioavailable IRAK4 Inhibitor. It exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation.
低至 ¥ 300 /5mg
Zabedosertib
Zabedosertib is a selective IRAK4 inhibitor with oral activity that can regulate immune responses.
低至 ¥ 260 /1mg
Zimlovisertib
Zimlovisertib (PF-06650833) is an effective, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) with an IC50 of 0.2 nM, and an IC50 of 2.4 nM in PBMC assays. Zimlovisertib has potential for research in rheumatoid arthritis, lupus, and lymphoma.
低至 ¥ 4096 /100mg
Danuglipron
PF-06882961 is a GLP-1R agonist. It works as a candidate drug for treatment for Type 2 Diabetes Mellitus in Phase 2 study.
低至 ¥ 294 /1mg
Eragidomide
Eragidomide is a selective Cereblon E3 ligase modulator that selectively targets GSPT1 for ubiquitination and proteasomal degradation through CRL4CRBN, making it significant for cancer research.
低至 ¥ 549 /10mg
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